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  1. No Access

    Article

    DICKKOPF-4 is induced by TCF/β-catenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis and is repressed by 1α,25-dihydroxyvitamin D3

    Aberrant activation of the Wnt/β-catenin signaling pathway is a hallmark of colon cancer. We show that the Wnt antagonist DICKKOPF-4 (DKK-4) gene is repressed by 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) in human c...

    N Pendás-Franco, J M García, C Peña, N Valle, H G Pálmer, M Heinäniemi… in Oncogene (2008)

  2. No Access

    Article

    ‘Loss of pigment epithelium-derived factor enables migration, invasion and metastatic spread of human melanoma’

    Pigment epithelium-derived factor (PEDF) is a multifunctional secreted glycoprotein that displays broad anti-tumor activity based on dual targeting of the tumor microenvironment (anti-angiogenic action) and th...

    J L Orgaz, O Ladhani, K S Hoek, A Fernández-Barral, D Mihic, O Aguilera… in Oncogene (2009)

  3. No Access

    Article

    Serum metabolome analysis by 1H-NMR reveals differences between chronic lymphocytic leukaemia molecular subgroups

    Chronic lymphocytic leukaemia (CLL) is a heterogeneous disease exhibiting variable clinical course and survival rates. Mutational status of the immunoglobulin heavy chain variable regions (IGHVs) of CLL cells ...

    D A MacIntyre, B Jiménez, E Jantus Lewintre, C Reinoso Martín, H Schäfer… in Leukemia (2010)

  4. No Access

    Article

    DUSP1/MKP1 promotes angiogenesis, invasion and metastasis in non-small-cell lung cancer

    DUSP1/MKP1 is a dual-specific phosphatase that regulates MAPKs activity, with an increasingly recognized role in tumor biology. To understand more about the involvement of DUSP1 in lung cancer, we performed ge...

    V Moncho-Amor, I Ibañez de Cáceres, E Bandres, B Martínez-Poveda, J L Orgaz… in Oncogene (2011)

  5. Article

    Open Access

    Patient self-management of oral anticoagulation with vitamin K antagonists in everyday practice: clinical outcomes in a single centre cohort after long-term follow-up

    Patient self-management (PSM) of vitamin K antagonists (VKA) seems a very promising model of care for oral anticoagulation in terms of efficacy and safety. In comparison with other management models of VKA the...

    M. Corrochano, B. Jiménez, J. Millón, I. Gich, M. Rambla… in BMC Cardiovascular Disorders (2020)

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  6. Article

    Open Access

    Bevacizumab dose adjustment to improve clinical outcomes of glioblastoma

    Glioblastoma (GBM) is one of the most aggressive and vascularized brain tumors in adults, with a median survival of 20.9 months. In newly diagnosed and recurrent GBM, bevacizumab demonstrated an increase in pr...

    N. García-Romero, I. Palacín-Aliana, R. Madurga, J. Carrión-Navarro… in BMC Medicine (2020)

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