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Article
Targeting central serotonergic neurons with lentiviral vectors based on a transcriptional amplification strategy
Numerous pathological processes have been linked to disorders of the central 5-hydroxytryptamine (5HT) system but the possibility of gene therapy through modulation of 5HT system remained unexplored due to the...
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Article
Repeated intrathecal administration of plasmid DNA complexed with polyethylene glycol-grafted polyethylenimine led to prolonged transgene expression in the spinal cord
Gene delivery into the spinal cord provides a potential approach to the treatment of spinal cord traumatic injury, amyotrophic lateral sclerosis, and spinal muscular atrophy. These disorders progress over long...
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Chapter
Molecular Markers, Forest Genetics, and Tree Breeding
Several years ago, Strauss et al. (1992) thoughtfully evaluated the application of molecular markers in forest tree breeding for marker aided selection. The purpose of their paper was to emphasize the limitati...