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  1. Article

    Open Access

    A phase I study of the combination of ro4929097 and cediranib in patients with advanced solid tumours (PJC-004/NCI 8503)

    The Notch signalling pathway has been implicated in tumour initiation, progression, angiogenesis and development of resistance to vascular endothelial growth factor (VEGF) targeting, providing a rationale for ...

    S Sahebjam, P L Bedard, V Castonguay, Z Chen, M Reedijk, G Liu in British Journal of Cancer (2013)

  2. Article

    Open Access

    A prognostic index for operable, node-negative breast cancer

    Clinical data and samples from patients diagnosed, more than 10 years previously, with operable node-negative breast cancer (participants in the Scottish Adjuvant Tamoxifen trial), were revisited. Cases with t...

    M McCallum, C Baker, K Gillespie, B Cohen, H Stewart in British Journal of Cancer (2004)

  3. No Access

    Article

    Chronic citicoline increases phosphodiesters in the brains of healthy older subjects: an in vivo phosphorus magnetic resonance spectroscopy study

    Rationale: Phosphatidylcholine (PtdCho) in brain cell membranes decreases with age. Evidence from both animal and in vitro studies indicates that CDP-choline (citicoline) administration may increase phosphatidylc...

    S. Babb, L. Wald, B. Cohen, R. Villafuerte, S. Gruber in Psychopharmacology (2002)

  4. No Access

    Article

    Vestibular control of sympathetic activity

    It has been proposed that a vestibular reflex originating in the otolith organs and other body graviceptors modulates sympathetic activity during changes in posture with regard to gravity. To test this hypothe...

    H. Kaufmann, I. Biaggioni, A. Voustianiouk, A. Diedrich in Experimental Brain Research (2002)

  5. Article

    Open Access

    Evidence of a founder BRCA1 mutation in Scotland

    BRCA1 mutations have been identified in breast and ovarian cancer families from diverse ethnic backgrounds. We studied 17 different families with the BRCA1 2800delAA mutation; seven were ascertained in Scotland ...

    A Liede, B Cohen, D M Black, R H Davidson, A Renwick in British Journal of Cancer (2000)

  6. No Access

    Article

    Effect of viewing distance on the generation of vertical eye movements during locomotion

    Vertical head and eye coordination was studied as a function of viewing distance during locomotion. Vertical head translation and pitch movements were measured using a video motion analysis system (Optotrak 30...

    S. T. Moore, E. Hirasaki, B. Cohen, T. Raphan in Experimental Brain Research (1999)

  7. No Access

    Article

    p53 mutations in cervical carcinogenesis – low frequency and lack of correlation with human papillomavirus status

    p53 gene aberrations are common in human malignancies, and recent studies suggest that in cervical carcinoma p53 function is inactivated either by complex formation with human papillomavirus (HPV) E6 product o...

    RMC Busby-Earle, CM Steel, ARW Williams, B Cohen, CC Bird in British Journal of Cancer (1994)

  8. No Access

    Chapter

    Receptor subtypes — Molecular biology and pharmacology

    Molecular cloning studies have demonstrated structural and functional diversity in neuronal nicotinic acetylcholine receptors. To date, seven a subunits (a2 to a8) and three α subunits (α2 to α4) have been cha...

    A. B. Elgoyhen, D. Johnson, J. Boulter in International Symposium on Nicotine: The E… (1994)

  9. No Access

    Article

    Effects of midline medullary lesions on velocity storage and the vestibulo-ocular reflex

    1. Crossing fibers were sectioned at the midline of the medulla caudal to the abducens nucleus in four cynomolgus monkeys. In two animals the lesions caused the time constant of horizontal and vertical per- an...

    E. Katz, J. M. B. Vianney de Jong, J. Buettner-Ennever in Experimental Brain Research (1991)

  10. No Access

    Article

    Effects of lesions of the nucleus of the optic tract on optokinetic nystagmus and after-nystagmus in the monkey

    1. The nucleus of the optic tract (NOT) and the dorsal terminal nucleus (DTN) of the accessory optic system were lesioned electrolytically or with kainic acid in rhesus monkeys. When lesions involved NOT and D...

    D. Schiff, B. Cohen, J. Büttner-Ennever, V. Matsuo in Experimental Brain Research (1990)

  11. No Access

    Article

    Eye movements induced by off-vertical axis rotation (OVAR) at small angles of tilt

    Off-vertical rotation (OVAR) in darkness induced continuous horizontal nystagmus in humans at small tilts of the rotation axis (5 to 30 degrees). The horizontal slow eye velocity had two components: a mean vel...

    C. Darlot, P. Denise, J. Droulez, B. Cohen, A. Berthoz in Experimental Brain Research (1988)

  12. No Access

    Article

    Motion perceptions induced by off-vertical axis rotation (OVAR) at small angles of tilt

    Off-vertical axis rotation in darkness induces a perception of body motion which lasts as long as rotation continues. Perceived body motion is the combination of two simultaneous displacements. The most easily...

    P. Denise, C. Darlot, J. Droulez, B. Cohen, A. Berthoz in Experimental Brain Research (1988)

  13. No Access

    Article

    Nystagmus induced by stimulation of the nucleus of the optic tract in the monkey

    1. The nucleus of the optic tract (NOT) was electrically stimulated in alert rhesus monkeys. In darkness stimulation evoked horizontal nystagmus with ipsilateral slow phases, followed by after-nystagmus in the...

    D. Schiff, B. Cohen, T. Raphan in Experimental Brain Research (1988)

  14. No Access

    Article

    Horizontal saccades induced by stimulation of the central mesencephalic reticular formation

    1. The central mesencephalic reticular formation (cMRF) was electrically stimulated in the alert monkey. Saccadi...

    B. Cohen, V. Matsuo, J. Fradin, T. Raphan in Experimental Brain Research (1985)

  15. No Access

    Article

    Projections from the superior colliculus to a region of the central mesencephalic reticular formation (cMRF) associated with horizontal saccadic eye movements

    Radioactive wheatgerm agglutinin (WGA) and horseradish peroxidase (HRP) were injected into portions of the mesencephalic reticular formation at sites where electrical stimulation induced either small or large ...

    B. Cohen, J. A. Büttner-Ennever in Experimental Brain Research (1984)

  16. No Access

    Article

    Velocity storage in the vestibulo-ocular reflex arc (VOR)

    Vestibular and optokinetic nystagmus (OKN) of monkeys were induced by platform and visual surround rotation. Vision prolonged per-rotatory nystagmus and cancelled or reduced post-rotatory nystagmus recorded in...

    Dr. Th. Raphan, V. Matsuo, B. Cohen in Experimental Brain Research (1979)

  17. No Access

    Book

  18. No Access

    Chapter

    The Vestibulo-Ocular Reflex Arc

    Three topics related to Vestibulo-Ocular Reflexes will be considered in this chapter: (1) The function of eye movements induced by the Vestibulo-Ocular Reflex Arc. (2) The pattern of eye movements induced by v...

    B. Cohen in Vestibular System Part 1: Basic Mechanisms (1974)