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Open AccessA phase I study of the combination of ro4929097 and cediranib in patients with advanced solid tumours (PJC-004/NCI 8503)
The Notch signalling pathway has been implicated in tumour initiation, progression, angiogenesis and development of resistance to vascular endothelial growth factor (VEGF) targeting, providing a rationale for ...
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Article
Open AccessA prognostic index for operable, node-negative breast cancer
Clinical data and samples from patients diagnosed, more than 10 years previously, with operable node-negative breast cancer (participants in the Scottish Adjuvant Tamoxifen trial), were revisited. Cases with t...
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Article
Chronic citicoline increases phosphodiesters in the brains of healthy older subjects: an in vivo phosphorus magnetic resonance spectroscopy study
Rationale: Phosphatidylcholine (PtdCho) in brain cell membranes decreases with age. Evidence from both animal and in vitro studies indicates that CDP-choline (citicoline) administration may increase phosphatidylc...
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Article
Vestibular control of sympathetic activity
It has been proposed that a vestibular reflex originating in the otolith organs and other body graviceptors modulates sympathetic activity during changes in posture with regard to gravity. To test this hypothe...
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Article
Open AccessEvidence of a founder BRCA1 mutation in Scotland
BRCA1 mutations have been identified in breast and ovarian cancer families from diverse ethnic backgrounds. We studied 17 different families with the BRCA1 2800delAA mutation; seven were ascertained in Scotland ...
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Article
Effect of viewing distance on the generation of vertical eye movements during locomotion
Vertical head and eye coordination was studied as a function of viewing distance during locomotion. Vertical head translation and pitch movements were measured using a video motion analysis system (Optotrak 30...
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Article
p53 mutations in cervical carcinogenesis – low frequency and lack of correlation with human papillomavirus status
p53 gene aberrations are common in human malignancies, and recent studies suggest that in cervical carcinoma p53 function is inactivated either by complex formation with human papillomavirus (HPV) E6 product o...
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Chapter
Receptor subtypes — Molecular biology and pharmacology
Molecular cloning studies have demonstrated structural and functional diversity in neuronal nicotinic acetylcholine receptors. To date, seven a subunits (a2 to a8) and three α subunits (α2 to α4) have been cha...
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Article
Effects of midline medullary lesions on velocity storage and the vestibulo-ocular reflex
1. Crossing fibers were sectioned at the midline of the medulla caudal to the abducens nucleus in four cynomolgus monkeys. In two animals the lesions caused the time constant of horizontal and vertical per- an...
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Article
Effects of lesions of the nucleus of the optic tract on optokinetic nystagmus and after-nystagmus in the monkey
1. The nucleus of the optic tract (NOT) and the dorsal terminal nucleus (DTN) of the accessory optic system were lesioned electrolytically or with kainic acid in rhesus monkeys. When lesions involved NOT and D...
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Article
Eye movements induced by off-vertical axis rotation (OVAR) at small angles of tilt
Off-vertical rotation (OVAR) in darkness induced continuous horizontal nystagmus in humans at small tilts of the rotation axis (5 to 30 degrees). The horizontal slow eye velocity had two components: a mean vel...
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Article
Motion perceptions induced by off-vertical axis rotation (OVAR) at small angles of tilt
Off-vertical axis rotation in darkness induces a perception of body motion which lasts as long as rotation continues. Perceived body motion is the combination of two simultaneous displacements. The most easily...
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Article
Nystagmus induced by stimulation of the nucleus of the optic tract in the monkey
1. The nucleus of the optic tract (NOT) was electrically stimulated in alert rhesus monkeys. In darkness stimulation evoked horizontal nystagmus with ipsilateral slow phases, followed by after-nystagmus in the...
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Article
Horizontal saccades induced by stimulation of the central mesencephalic reticular formation
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The central mesencephalic reticular formation (cMRF) was electrically stimulated in the alert monkey. Saccadi...
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Projections from the superior colliculus to a region of the central mesencephalic reticular formation (cMRF) associated with horizontal saccadic eye movements
Radioactive wheatgerm agglutinin (WGA) and horseradish peroxidase (HRP) were injected into portions of the mesencephalic reticular formation at sites where electrical stimulation induced either small or large ...
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Article
Velocity storage in the vestibulo-ocular reflex arc (VOR)
Vestibular and optokinetic nystagmus (OKN) of monkeys were induced by platform and visual surround rotation. Vision prolonged per-rotatory nystagmus and cancelled or reduced post-rotatory nystagmus recorded in...
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Book
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Chapter
The Vestibulo-Ocular Reflex Arc
Three topics related to Vestibulo-Ocular Reflexes will be considered in this chapter: (1) The function of eye movements induced by the Vestibulo-Ocular Reflex Arc. (2) The pattern of eye movements induced by v...