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  1. Article

    Open Access

    Genomic analysis of advanced breast cancer tumors from talazoparib-treated gBRCA1/2mut carriers in the ABRAZO study

    These analyses explore the impact of homologous recombination repair gene mutations, including BRCA1/2 mutations and homologous recombination deficiency (HRD), on the efficacy of the poly(ADP-ribose) polymerase (...

    Nicholas C. Turner, A. Douglas Laird, Melinda L. Telli, Hope S. Rugo… in npj Breast Cancer (2023)

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    Article

    Outcomes of patients with HER2-negative metastatic breast cancer after platinum- and non-platinum-based first-line chemotherapy among patients with and without pathogenic germline BRCA1/2 mutations

    The efficacy and added benefit of platinum-based chemotherapy (PtCT) for metastatic breast cancer (MBC) remain unclear in patients with and without germline BRCA1 or BRCA2 mutations (gBRCA1/2m and gBRCA1/2wt, res...

    William Jacot, Amélie Lusque, Cécile Vicier, Audrey Mailliez… in British Journal of Cancer (2022)