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  1. No Access

    Article

    Systematic discovery and perturbation of regulatory genes in human T cells reveals the architecture of immune networks

    Gene regulatory networks ensure that important genes are expressed at precise levels. When gene expression is sufficiently perturbed, it can lead to disease. To understand how gene expression disruptions perco...

    Jacob W. Freimer, Oren Shaked, Sahin Naqvi, Nasa Sinnott-Armstrong… in Nature Genetics (2022)

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    Article

    The dynamic, combinatorial cis-regulatory lexicon of epidermal differentiation

    Transcription factors bind DNA sequence motif vocabularies in cis-regulatory elements (CREs) to modulate chromatin state and gene expression during cell state transitions. A quantitative understanding of how moti...

    Daniel S. Kim, Viviana I. Risca, David L. Reynolds, James Chappell… in Nature Genetics (2021)

  3. No Access

    Article

    Landscape of stimulation-responsive chromatin across diverse human immune cells

    A hallmark of the immune system is the interplay among specialized cell types transitioning between resting and stimulated states. The gene regulatory landscape of this dynamic system has not been fully charac...

    Diego Calderon, Michelle L. T. Nguyen, Anja Mezger, Arwa Kathiria… in Nature Genetics (2019)