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  1. No Access

    Article

    In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer

    The immune system can eliminate tumors, but checkpoints enable immune escape. Here, we identify immune evasion mechanisms using genome-scale in vivo CRISPR screens across cancer models treated with immune chec...

    Juan Dubrot, Peter P. Du, Sarah Kate Lane-Reticker, Emily A. Kessler… in Nature Immunology (2022)

  2. Article

    Open Access

    Chronic alcohol-induced neuroinflammation involves CCR2/5-dependent peripheral macrophage infiltration and microglia alterations

    Chronic alcohol consumption is associated with neuroinflammation, neuronal damage, and behavioral alterations including addiction. Alcohol-induced neuroinflammation is characterized by increased expression of ...

    Patrick P. Lowe, Caroline Morel, Aditya Ambade… in Journal of Neuroinflammation (2020)

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  3. Article

    Open Access

    Reduced gut microbiome protects from alcohol-induced neuroinflammation and alters intestinal and brain inflammasome expression

    The end-organ effects of alcohol span throughout the entire body, from the gastrointestinal tract to the central nervous system (CNS). In the intestine, alcohol use changes the microbiome composition and incre...

    Patrick P. Lowe, Benedek Gyongyosi, Abhishek Satishchandran… in Journal of Neuroinflammation (2018)

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  4. No Access

    Article

    IL-1α in acetaminophen toxicity: a sterile danger signal

    Arvin Iracheta-Vellve, Gyongyi Szabo in Cellular & Molecular Immunology (2018)