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  1. No Access

    Article

    In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer

    The immune system can eliminate tumors, but checkpoints enable immune escape. Here, we identify immune evasion mechanisms using genome-scale in vivo CRISPR screens across cancer models treated with immune chec...

    Juan Dubrot, Peter P. Du, Sarah Kate Lane-Reticker, Emily A. Kessler… in Nature Immunology (2022)

  2. No Access

    Article

    IL-1α in acetaminophen toxicity: a sterile danger signal

    Arvin Iracheta-Vellve, Gyongyi Szabo in Cellular & Molecular Immunology (2018)

  3. No Access

    Article

    Gap junction inhibition prevents drug-induced liver toxicity and fulminant hepatic failure

    Liver toxicity is one of the most common reasons for abandoning new drugs in development or withdrawing approved drugs from the market. Patel et al. show that in mice drug-induced liver injury can be limited by s...

    Suraj J Patel, Jack M Milwid, Kevin R King, Stefan Bohr… in Nature Biotechnology (2012)