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Open AccessExamining confidential wholesale margin estimates in European countries for the price negotiation of patented drugs in Germany: a statistical model
Based on the legal framework laid down in section 130b (9) of Book V of the German Social Code, various criteria are relevant for the negotiated price for new patented drugs in Germany. European reference pric...
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Open AccessCan adaptive clinical trials help to solve the productivity crisis of the pharmaceutical industry? - a scenario analysis
The productivity of pharmaceutical research and development (R&D) investments is declining due to high failure rates in clinical research. Recently, the US Food and Drug Administration (FDA) acknowledged that ...