3 Result(s)

Article

Cerebral organoids with chromosome 21 trisomy secrete Alzheimer’s disease-related soluble aggregates detectable by single-molecule-fluorescence and super-resolution microscopy

Understanding the role of small, soluble aggregates of beta-amyloid (Aβ) and tau in Alzheimer’s disease (AD) is of great importance for the rational design of preventative therapies. Here we report a set of me...

Emre Fertan, Dorothea Böken, Aoife Murray, John S. H. Danial… in Molecular Psychiatry (2024)

Article

Correction: Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain

Ivan Alić, Pollyanna A. Goh, Aoife Murray, Erik Portelius… in Molecular Psychiatry (2021)

Article

Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain

A population of more than six million people worldwide at high risk of Alzheimer’s disease (AD) are those with Down Syndrome (DS, caused by trisomy 21 (T21)), 70% of whom develop dementia during lifetime, caus...

Ivan Alić, Pollyanna A. Goh, Aoife Murray, Erik Portelius… in Molecular Psychiatry (2021)