7 Result(s)

Article

Comparison of targeted next-generation sequencing and Sanger sequencing for the detection of PIK3CA mutations in breast cancer

Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, PIK3CA, is one of the most frequently mutated genes in breast cancer, and the mutation status of PIK3CA has clinical relevance related to r...

Ruza Arsenic, Denise Treue, Annika Lehmann, Michael Hummel… in BMC Clinical Pathology (2015)

Article

Single-cell RNA sequencing reveals distinct tumor microenvironmental patterns in lung adenocarcinoma

Recent developments in immuno-oncology demonstrate that not only cancer cells, but also the tumor microenvironment can guide precision medicine. A comprehensive and in-depth characterization of the tumor micro...

Philip Bischoff, Alexandra Trinks, Benedikt Obermayer, Jan Patrick Pett… in Oncogene (2021)

Article

Comparison of risk assessment in 1652 early ER positive, HER2 negative breast cancer in a real-world data set: classical pathological parameters vs. 12-gene molecular assay (EndoPredict)

Risk assessment on the molecular level is important in predictive pathology to determine the risk of metastatic disease for ERpos, HER2neg breast cancer. The gene expression test EndoPredict (EP) was trained a...

Paul Jank, Judith Lea Lindner, Annika Lehmann… in Breast Cancer Research and Treatment (2022)

Article

Response prediction in patients with gastric and esophagogastric adenocarcinoma under neoadjuvant chemotherapy using targeted gene expression analysis and next-generation sequencing in pre-therapeutic biopsies

Perioperative chemo-(radio-) therapy is the accepted standard in European patients with locally advanced adenocarcinoma of the esophagogastric junction or stomach (AEG/AS). However, 30–85% of patients do not r...

Karsten Kleo, Vladimir M. Jovanovic… in Journal of Cancer Research and Clinical On… (2023)

Article

Proficiency testing of PIK3CA mutations in HR+/HER2-breast cancer on liquid biopsy and tissue

Precision oncology based on specific molecular alterations requires precise and reliable detection of therapeutic targets in order to initiate the optimal treatment. In many European countries—including German...

Claudia Vollbrecht, Inga Hoffmann, Annika Lehmann… in Virchows Archiv (2023)

Article

MET receptor serves as a promising target in melanoma brain metastases

The development of brain metastases hallmarks disease progression in 20–40% of melanoma patients and is a serious obstacle to therapy. Understanding the processes involved in the development and maintenance of...

Torben Redmer, Elisa Schumann, Kristin Peters… in Acta Neuropathologica (2024)

Article

Correction to: MET receptor serves as a promising target in melanoma brain metastases

Torben Redmer, Elisa Schumann, Kristin Peters… in Acta Neuropathologica (2024)