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  1. Article

    Open Access

    Evaluation of a laboratory-based high-throughput SARS-CoV-2 antigen assay for non-COVID-19 patient screening at hospital admission

    Several rapid antigen tests (RATs) for the detection of SARS-CoV-2 were evaluated recently. However, reliable performance data for laboratory-based, high-throughput antigen tests are lacking. Therefore and in ...

    Friederike Häuser, Martin F. Sprinzl, Kim J. Dreis… in Medical Microbiology and Immunology (2021)

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    Article

    Transcripts expressed in cytomegalovirus latency coding for an antigenic IE/E phase peptide that drives “memory inflation”

    Roizman’s definition of herpesviral latency, which applies also to cytomegaloviruses (CMVs), demands maintenance of reactivation-competent viral genomes after clearance of productive infection. It is more rece...

    Angelique Renzaho, Julia K. Schmiedeke… in Medical Microbiology and Immunology (2019)

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    Article

    Identification of an atypical CD8 T cell epitope encoded by murine cytomegalovirus ORF-M54 gaining dominance after deletion of the immunodominant antiviral CD8 T cell specificities

    Control of murine cytomegalovirus (mCMV) infection is mediated primarily by CD8 T cells, with four specificities dominating in BALB/c mice. Functional deletion of the respective immunodominant epitopes (IDEs) ...

    Rafaela Holtappels, Niels A. W. Lemmermann… in Medical Microbiology and Immunology (2015)

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    Article

    Mast cells as rapid innate sensors of cytomegalovirus by TLR3/TRIF signaling-dependent and -independent mechanisms

    The succinct metaphor, ‘the immune system's loaded gun', has been used to describe the role of mast cells (MCs) due to their storage of a wide range of potent pro-inflammatory and antimicrobial mediators in se...

    Marc Becker, Niels AW Lemmermann, Stefan Ebert… in Cellular & Molecular Immunology (2015)

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    Article

    Viral latency drives ‘memory inflation’: a unifying hypothesis linking two hallmarks of cytomegalovirus infection

    Low public awareness of cytomegalovirus (CMV) results from the only mild and transient symptoms that it causes in the healthy immunocompetent host, so that primary infection usually goes unnoticed. The virus i...

    Christof K. Seckert, Marion Grießl, Julia K. Büttner… in Medical Microbiology and Immunology (2012)

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    Article

    Immune control in the absence of immunodominant epitopes: implications for immunotherapy of cytomegalovirus infection with antiviral CD8 T cells

    Adoptive transfer of virus-specific donor-derived CD8 T cells is a therapeutic option to prevent cytomegalovirus (CMV) disease in recipients of hematopoietic cell transplantation. Due to their high coding capa...

    Stefan Ebert, Niels A. W. Lemmermann, Doris Thomas… in Medical Microbiology and Immunology (2012)

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    Article

    Hematopoietic stem cell transplantation with latently infected donors does not transmit virus to immunocompromised recipients in the murine model of cytomegalovirus infection

    Hematopoietic stem cell transplantation (HSCT) bears a risk of reactivating latent cytomegalovirus (CMV) in either the transplanted hematopoietic donor cells or in parenchymal and stromal tissue cells of the i...

    Christof K. Seckert, Angélique Renzaho… in Medical Microbiology and Immunology (2008)