5 Result(s)
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Andrew J. Pocklington
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Article
Open AccessTranscriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants
Coordinated programs of gene expression drive brain development. It is unclear which transcriptional programs, in which cell-types, are affected in neuropsychiatric disorders such as schizophrenia. Here we int...
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Article
Open AccessGenetic association of FMRP targets with psychiatric disorders
Genes encoding the mRNA targets of fragile X mental retardation protein (FMRP) are enriched for genetic association with psychiatric disorders. However, many FMRP targets possess functions that are themselves ...
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Article
Open AccessPolygenic risk for schizophrenia and subcortical brain anatomy in the UK Biobank cohort
Research has shown differences in subcortical brain volumes between participants with schizophrenia and healthy controls. However, none of these differences have been found to associate with schizophrenia poly...
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Article
Publisher Correction: Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessDynamic expression of genes associated with schizophrenia and bipolar disorder across development
Common genetic variation contributes a substantial proportion of risk for both schizophrenia and bipolar disorder. Furthermore, there is evidence of significant, but not complete, overlap in genetic risk betwe...
