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  1. No Access

    Article

    Map** genomic loci implicates genes and synaptic biology in schizophrenia

    Schizophrenia has a heritability of 60–80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 con...

    Vassily Trubetskoy, Antonio F. Pardiñas, Ting Qi, Georgia Panagiotaropoulou… in Nature (2022)

  2. Article

    Open Access

    Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants

    Coordinated programs of gene expression drive brain development. It is unclear which transcriptional programs, in which cell-types, are affected in neuropsychiatric disorders such as schizophrenia. Here we int...

    Bret Sanders, Daniel D’Andrea, Mark O. Collins, Elliott Rees… in Nature Communications (2022)

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  3. No Access

    Article

    De novo mutations in schizophrenia implicate synaptic networks

    Inherited alleles account for most of the genetic risk for schizophrenia. However, new (de novo) mutations, in the form of large chromosomal copy number changes, occur in a small fraction of cases and disproporti...

    Menachem Fromer, Andrew J. Pocklington, David H. Kavanagh, Hywel J. Williams… in Nature (2014)