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Article
Open AccessComputational approaches identify a transcriptomic fingerprint of drug-induced structural cardiotoxicity
Structural cardiotoxicity (SCT) presents a high-impact risk that is poorly tolerated in drug discovery unless significant benefit is anticipated. Therefore, we aimed to improve the mechanistic understanding of...
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Article
Open AccessAn immunomodulating peptide to counteract solar radiation-induced immunosuppression and DNA damage
Ultraviolet radiation (UVR) induces immunosuppression and DNA damage, both of which contribute to the rising global incidence of skin cancer including melanoma. Nucleotide excision repair, which is activated u...
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Article
Open AccessIntrinsic TGF-β signaling attenuates proximal tubule mitochondrial injury and inflammation in chronic kidney disease
Excessive TGF-β signaling and mitochondrial dysfunction fuel chronic kidney disease (CKD) progression. However, inhibiting TGF-β failed to impede CKD in humans. The proximal tubule (PT), the most vulnerable re...
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Article
Open AccessCharacterisation and induction of tissue-resident gamma delta T-cells to target hepatocellular carcinoma
Immunotherapy is now the standard of care for advanced hepatocellular carcinoma (HCC), yet many patients fail to respond. A major unmet goal is the boosting of T-cells with both strong HCC reactivity and the p...
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Article
Open AccessThe ultrasound competency assessment tool for four-view cardiac POCUS
Point-of-care ultrasound (POCUS) has been recognized as an essential skill across medicine. However, a lack of reliable and streamlined POCUS assessment tools with demonstrated validity remains a significant b...
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Article
Open AccessCollagen and elastic fibres in acute and chronic liver injury
The histological distinction between acute and chronic liver injury is a challenging aspect of liver histopathology. It is traditionally based on the interpretation of morphological changes to the extracellula...
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Article
Open AccessElastic fibres in alcoholic liver disease
The literature on the contribution of elastic fibre deposition to alcohol-related liver disease (ARLD) is limited. We studied: (1) 180 liver biopsies from ARLD patients; (2) 20 ARLD explant livers; (3) 213 liv...
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Article
Open AccessThe evaluation of Suchana, a large-scale development program to prevent chronic undernutrition in north-eastern Bangladesh
Evidence of the impact of community-based nutrition programs is uncommon for two main reasons: the lack of untreated controls, and implementation does not account for the evaluation design. Suchana is a large-sca...
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Article
Open AccessDoes quality of care in hip fracture vary by day of admission?
This study investigates if the day of the week a person is admitted with a hip fracture influences the quality of care they receive. We found those admitted Thursday and Friday were likely to obtain poorer pos...
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Article
Open AccessClinicopathological correlations of mesenteric fibrosis and evaluation of a novel biomarker for fibrosis detection in small bowel neuroendocrine neoplasms
Mesenteric fibrosis (MF) in small intestinal neuroendocrine neoplasms (SINENs) is often associated with significant morbidity and mortality. The detection of MF is usually based on radiological criteria, but n...
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Article
Open AccessInvestigating the potential clinical benefit of Selumetinib in resensitising advanced iodine refractory differentiated thyroid cancer to radioiodine therapy (SEL-I-METRY): protocol for a multicentre UK single arm phase II trial
Thyroid cancer is the most common endocrine malignancy. Some advanced disease is, or becomes, resistant to radioactive iodine therapy (refractory disease); this holds poor prognosis of 10% 10-year overall surv...
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Article
Open AccessThe endogenous subcellular localisations of the long chain fatty acid-activating enzymes ACSL3 and ACSL4 in sarcoma and breast cancer cells
Fatty acid uptake and metabolism are often dysregulated in cancer cells. Fatty acid activation is a critical step that allows these biomolecules to enter cellular metabolic pathways such as mitochondrial β-oxi...
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Article
Open AccessWhy do many pheasants released in the UK die, and how can we best reduce their natural mortality?
Around 60% of pheasants released for shooting in the UK, an estimated 21 million birds, do not end up at their intended fate: being shot. This constitutes wastage, raising economic, environmental and ethical q...
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Article
Open AccessRapid production of human liver scaffolds for functional tissue engineering by high shear stress oscillation-decellularization
The development of human liver scaffolds retaining their 3-dimensional structure and extra-cellular matrix (ECM) composition is essential for the advancement of liver tissue engineering. We report the design a...
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Article
Open AccessCost of the Diet: a method and software to calculate the lowest cost of meeting recommended intakes of energy and nutrients from local foods
When food is available, the main obstacle to access is usually economic: people may not be able to afford a nutritious diet, even if they know what foods to eat. The Cost of the Diet method and software was de...
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Article
Open AccessTransaminase abnormalities and adaptations of the liver lobule manifest at specific cut-offs of steatosis
There is little documented evidence suggesting that liver fat is responsible for liver injury in the absence of other disease processes. We investigated the relationships between liver fat, aminotransferases a...
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Article
Open AccessResearch priorities for improving infant and young child feeding in humanitarian emergencies
There are many challenges during emergencies to ensure that optimal infant and young child feeding is protected, promoted and supported, but there is a dearth of evidence on strategies and programmes to improv...
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Article
Open AccessMethods of nutrition surveillance in low-income countries
In 1974 a joint FAO/UNICEF/WHO Expert Committee met to develop methods for nutrition surveillance. There has been much interest and activity in this topic since then, however there is a lack of guidance for pr...
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Article
Open AccessThe role of nutrition in integrated programs to control neglected tropical diseases
There are strong and direct relationships between undernutrition and the disease caused by infectious organisms, including the diverse pathogens labeled as neglected tropical diseases (NTDs). Undernutrition in...
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Article
Open AccessSeroprevalence of hepatitis B and C virus in HIV-1 and HIV-2 infected Gambians
The prevalence of HIV/hepatitis co-infection in sub-Saharan Africa is not well documented, while both HIV and HBV are endemic in this area.
