11 Result(s)
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An-** Su
Biomedicine
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Article
SHP2: its association and roles in systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease. Src homology 2 domain containing protein tyrosine phosphatase (SHP2) is a member of the protein tyrosine phosphatases (PTPs) family. To...
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IL-38, a potential therapeutic agent for lupus, inhibits lupus progression
Previous studies reported that IL-38 was abnormally expressed in patients with systemic lupus erythematosus (SLE). However, the involvement of IL-38 in the pathophysiology of SLE remains unknown.
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Open AccessPharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma
HDAC inhibitors (HDACis) have been intensively studied for their roles and potential as drug targets in T-cell lymphomas and other hematologic malignancies. Bisthianostat is a novel bisthiazole-based pan-HDACi...
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Open AccessHDAC6 involves in regulating the lncRNA-microRNA-mRNA network to promote the proliferation of glioblastoma cells
Glioblastoma (GBM) is the most aggressive and lethal brain tumor. Although the histone deacetylase (HDAC)/transcription factor axis promotes growth in GBM, whether HDACs including HDAC6 are involved in modulat...
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Open AccessAbstracts from the 8th International Congress of the Asia Pacific Society of Infection Control (APSIC)
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Article
Low-Dose Ethanol Preconditioning Protects Against Oxygen-Glucose Deprivation/Reoxygenation-Induced Neuronal Injury By Activating Large Conductance, Ca2+-Activated K+ Channels In Vitro
Increasing evidence suggests that low to moderate ethanol ingestion protects against the deleterious effects of subsequent ischemia/reperfusion; however, the underlying mechanism has not been elucidated. In th...
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Functional characterization of TRPM7 in nasopharyngeal carcinoma and its knockdown effects on tumorigenesis
The aim of this study was to evaluate the association of functional expression of TRPM7 with nasopharyngeal carcinoma (NPC) growth. We examined the correlation of TRPM7 expression with cell growth and prolifer...
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Open AccessRickettsia raoultii in Haemaphysalis erinacei from marbled polecats, China–Kazakhstan border
We found Rickettsia raoultii DNA in 2 out of 32 (6.25 %) Haemaphysalis erinacei ticks. Result showed that the sequences of five genes (17-kDa, gltA, ompA, rrs, and ompB) were 100 % identity with that of R. Raoult...
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Article
Comparison of the cardiac electrophysiological effects between doxazosin and bunazosin
In Langendorff-perfused adult rat heart with constant pressure at 80 mmHg, we found doxazosin, an α1 adrenoceptor blocker, at 10 μM prolonged PR interval and induced occasional arrhythmia followed by complete inh...
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Comparison of the cardiac effects between quinazoline-based α1-adrenoceptor antagonists on occlusion–reperfusion injury
Quinazoline-based compounds such as prazosin and its congeners including doxazosin, bunazosin, and terazosin are widely used as antihypertensive agents. However, there were many clinical observations showing t...
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Antihyperglycemic effects of total ginsenosides from leaves and stem of Panax ginseng
The antihyperglycemic effects of the total ginsenosides in Chinese ginseng (TGCG), extracted from leaves and the stem, were evaluated in diabetic C57BL/6J ob/ob mice.
