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Open AccessNF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus
NF-κB-inducing kinase (NIK) mediates non-canonical NF-κB signaling downstream of multiple TNF family members, including BAFF, TWEAK, CD40, and OX40, which are implicated in the pathogenesis of systemic lupus e...
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Open AccessIL-22 alters gut microbiota composition and function to increase aryl hydrocarbon receptor activity in mice and humans
IL-22 is induced by aryl hydrocarbon receptor (AhR) signaling and plays a critical role in gastrointestinal barrier function through effects on antimicrobial protein production, mucus secretion, and epithelial...
