8 Result(s)

Article

Author Correction: Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials

Cathrine Axfors, Andreas M. Schmitt, Perrine Janiaud… in Nature Communications (2024)

Article

Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira, Konrad Rawlik, Andrew D. Bretherick, Ting Qi, Yang Wu… in Nature (2023)

Article

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown¹ to be highly efficient for discovery of genetic associations². Despite the advanced stage of ...

Erola Pairo-Castineira, Konrad Rawlik, Andrew D. Bretherick, Ting Qi, Yang Wu… in Nature (2023)

Article

Comparative effectiveness of neutralising monoclonal antibodies in high risk COVID-19 patients: a Bayesian network meta-analysis

The purpose of this work was to review and synthesise the evidence on the comparative effectiveness of neutralising monoclonal antibody (nMAB) therapies in individuals exposed to or infected with SARS-CoV-2 an...

David McConnell, Marie Harte, Cathal Walsh, Desmond Murphy… in Scientific Reports (2022)

Article

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care¹ or hospitalization^2–4 after infection with SARS-CoV-2...

Athanasios Kousathanas, Erola Pairo-Castineira, Konrad Rawlik, Alex Stuckey… in Nature (2022)

Article

Author Correction: Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials

Cathrine Axfors, Andreas M. Schmitt, Perrine Janiaud… in Nature Communications (2021)

Article

Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials

Substantial COVID-19 research investment has been allocated to randomized clinical trials (RCTs) on hydroxychloroquine/chloroquine, which currently face recruitment challenges or early discontinuation. We aim ...

Cathrine Axfors, Andreas M. Schmitt, Perrine Janiaud… in Nature Communications (2021)

Article

Genetic mechanisms of critical illness in COVID-19

Host-mediated lung inflammation is present¹, and drives mortality², in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mecha...

Erola Pairo-Castineira, Sara Clohisey, Lucija Klaric, Andrew D. Bretherick… in Nature (2021)