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  1. Article

    Open Access

    Pharmacological activation of pyruvate kinase M2 reprograms glycolysis leading to TXNIP depletion and AMPK activation in breast cancer cells

    Aerobic glycolysis, discovered by Otto Warburg, is a hallmark of cancer metabolism even though not yet fully understood. The low activity of the cancerous pyruvate kinase isozyme (M2) is thought to play an imp...

    Fadi Almouhanna, Biljana Blagojevic, Suzan Can, Ali Ghanem… in Cancer & Metabolism (2021)

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