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Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

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  1. Article

    Open Access

    Nociceptor neurons affect cancer immunosurveillance

    Solid tumours are innervated by nerve fibres that arise from the autonomic and sensory peripheral nervous systems1–5. Whether the neo-innervation of tumours by pain-initiating sensory neurons affects cancer immun...

    Mohammad Balood, Maryam Ahmadi, Tuany Eichwald, Ali Ahmadi, Abdelilah Majdoubi… in Nature (2022)

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  2. Article

    Open Access

    Mitigation of off-target toxicity in CRISPR-Cas9 screens for essential non-coding elements

    Pooled CRISPR-Cas9 screens are a powerful method for functionally characterizing regulatory elements in the non-coding genome, but off-target effects in these experiments have not been systematically evaluated...

    Josh Tycko, Michael Wainberg, Georgi K. Marinov, Oana Ursu… in Nature Communications (2019)

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