Skip to main content

3 Result(s)

within Alexander E. Lang Remove this filter Science, multidisciplinary Remove this filter

and

  1. Article

    Open Access

    The Escherichia coli effector EspJ blocks Src kinase activity via amidation and ADP ribosylation

    The hallmark of enteropathogenic Escherichia coli (EPEC) infection is the formation of actin-rich pedestal-like structures, which are generated following phosphorylation of the bacterial effector Tir by cellular ...

    Joanna C. Young, Abigail Clements, Alexander E. Lang… in Nature Communications (2014)

    Download PDF (1646 KB) View Article

  2. No Access

    Article

    Mechanism of Tc toxin action revealed in molecular detail

    Tripartite Tc toxin complexes of bacterial pathogens perforate the host membrane and translocate toxic enzymes into the host cell, including in humans. The underlying mechanism is complex but poorly understood...

    Dominic Meusch, Christos Gatsogiannis, Rouslan G. Efremov, Alexander E. Lang… in Nature (2014)

  3. No Access

    Article

    A syringe-like injection mechanism in Photorhabdus luminescens toxins

    The TcA component of Photorhabdus luminescens ABC-type toxin complexes forms a transmembrane pore and injects TcC, the functional component of the toxin, into the target cell by means of a syringe-like mechanism.

    Christos Gatsogiannis, Alexander E. Lang, Dominic Meusch, Vanda Pfaumann… in Nature (2013)