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  1. No Access

    Article

    DeActs: genetically encoded tools for perturbing the actin cytoskeleton in single cells

    DeActs are genetically encoded tools that perturb the actin cytoskeleton. In contrast to drugs such as latrunculin, they can be targeted to specific cell types, which is demonstrated in the develo** mouse br...

    Martin Harterink, Marta Esteves da Silva, Lena Will, Julia Turan… in Nature Methods (2017)

  2. No Access

    Chapter

    Photorhabdus luminescens Toxins TccC3 and TccC5 Affect the Interaction of Actin with Actin-Binding Proteins Essential for Treadmilling

    Actin is one of the most abundant cellular proteins and an essential constituent of the actin cytoskeleton, which by its dynamic behavior participates in many cellular activities. The organization of the actin...

    Alexander E. Lang, Sonja Kühn… in The Actin Cytoskeleton and Bacterial Infec… (2017)

  3. No Access

    Chapter

    ADP-Ribosylation and Cross-Linking of Actin by Bacterial Protein Toxins

    Actin and the actin cytoskeleton play fundamental roles in host–pathogen interactions. Proper function of the actin cytoskeleton is crucial for innate and acquired immune defense. Bacterial toxins attack the a...

    Klaus Aktories, Carsten Schwan, Alexander E. Lang in The Actin Cytoskeleton (2017)

  4. No Access

    Chapter

    Photorhabdus luminescens Toxins TccC3 and TccC5: Insecticidal ADP-Ribosyltransferases that Modify Threonine and Glutamine

    The ADP-ribosyltransferases TccC3 and TccC5 are the biologically active TcC components of the tripartite Photorhabdus luminescens Tc toxin, which consist of TcA, TcB, and TcC components. TcA is the binding and me...

    Klaus Aktories, Gudula Schmidt, Alexander E. Lang in Endogenous ADP-Ribosylation (2015)

  5. Article

    Open Access

    The Escherichia coli effector EspJ blocks Src kinase activity via amidation and ADP ribosylation

    The hallmark of enteropathogenic Escherichia coli (EPEC) infection is the formation of actin-rich pedestal-like structures, which are generated following phosphorylation of the bacterial effector Tir by cellular ...

    Joanna C. Young, Abigail Clements, Alexander E. Lang… in Nature Communications (2014)

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  6. No Access

    Article

    Mechanism of Tc toxin action revealed in molecular detail

    Tripartite Tc toxin complexes of bacterial pathogens perforate the host membrane and translocate toxic enzymes into the host cell, including in humans. The underlying mechanism is complex but poorly understood...

    Dominic Meusch, Christos Gatsogiannis, Rouslan G. Efremov, Alexander E. Lang… in Nature (2014)

  7. No Access

    Article

    A syringe-like injection mechanism in Photorhabdus luminescens toxins

    The TcA component of Photorhabdus luminescens ABC-type toxin complexes forms a transmembrane pore and injects TcC, the functional component of the toxin, into the target cell by means of a syringe-like mechanism.

    Christos Gatsogiannis, Alexander E. Lang, Dominic Meusch, Vanda Pfaumann… in Nature (2013)

  8. No Access

    Article

    Targeting of the actin cytoskeleton by insecticidal toxins from Photorhabdus luminescens

    Photorhabdus luminescens produces several types of protein toxins, which are essential for participation in a trilateral symbiosis with nematodes and insects. The nematodes, carrying the bacteria, invade insect l...

    Alexander E. Lang, Gudula Schmidt… in Naunyn-Schmiedeberg's Archives of Pharmaco… (2011)