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Article
Open AccessEvidence of selection for an accessible nucleosomal array in human
Recently, a physical model of nucleosome formation based on sequence-dependent bending properties of the DNA double-helix has been used to reveal some enrichment of nucleosome-inhibiting energy barriers (NIEBs...
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Article
Perinuclear distribution of heterochromatin in develo** C. elegans embryos
Specific nuclear domains are nonrandomly positioned within the nuclear space, and this preferential positioning has been shown to play an important role in genome activity and stability. Well-known examples in...
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Article
Open AccessAnalysis of fine-scale mammalian evolutionary breakpoints provides new insight into their relation to genome organisation
The Intergenic Breakage Model, which is the current model of structural genome evolution, considers that evolutionary rearrangement breakages happen with a uniform propensity along the genome but are selected ...
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Article
Chromosome neighborhood composition determines translocation outcomes after exposure to high-dose radiation in primary cells
Radiation exposure is an occupational hazard for military personnel, some health care professionals, airport security screeners, and medical patients, with some individuals at risk for acute, high-dose exposur...