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Article
Functional metabolomics characterizes the contribution of farnesoid X receptor in pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome
Consumption of herbal products containing pyrrolizidine alkaloids (PAs) is one of the major causes for hepatic sinusoidal obstruction syndrome (HSOS), a deadly liver disease. However, the crucial metabolic var...
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Article
Hyperoside attenuates pyrrolizidine alkaloids-induced liver injury by ameliorating TFEB-mediated mitochondrial dysfunction
Pyrrolizidine alkaloids (PAs) are potent hepatotoxins that can cause liver damage. Hyperoside (Hyp), a natural flavonoid, can be extracted from medicinal plants. Hyp displays hepatoprotective activity in vario...
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Article
Enhanced high-temperature piezoelectric properties of Bi(Zn0.5Ti0.5)O3-modified BiFeO3–BaTiO3 ceramics
This paper reports enhanced high-temperature piezoelectric properties of Bi(Zn0.5Ti0.5)O3-modified BiFeO3-BaTiO3 (BF–BT-xBZT) ceramics prepared by two-step sintering method. The resultant ceramics show a symmetri...
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Article
Open AccessA TMT-based shotgun proteomics uncovers overexpression of thrombospondin 1 as a contributor in pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome
Hepatic sinusoidal obstruction disease (HSOS) is a rare but life-threatening vascular liver disease. However, its underlying mechanism and molecular changes in HSOS are largely unknown, thus greatly hindering ...
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Article
Comprehensive Analysis of Serum and Fecal Bile Acid Profiles and Interaction with Gut Microbiota in Primary Biliary Cholangitis
Accumulation of bile acids (BAs) contributes significantly to the pathogenesis of primary biliary cholangitis (PBC). Here, we sought to systematically characterize the serum and fecal BA profiles and the linka...
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Article
Evaluation of a Potential Clinical Significant Drug-Drug Interaction between Digoxin and Bupropion in Cynomolgus Monkeys
A three-period digoxin-bupropion drug-drug interaction study was performed in cynomolgus monkeys to assess the effect of bupropion and its metabolites on digoxin disposition.
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Article
Effects of Mn do** on the dielectric properties of (Pb,La,Sr)(Zr,Sn,Ti,Nb)O3 antiferroelectric ceramics
(Pb,La,Sr)(Zr,Sn,Ti,Nb)O3 + xmol% MnO2 (PLSZSTNM) ceramics with broad working temperature are fabricated by a wet-chemistry method. The effects of Mn-do** on dielectric breakdown strength, morphology, temperatu...
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Article
Sr2+ do** to enhanced energy-storage properties of (Na0.5Bi0.5)0.94Ba0.06TiO3 lead-free ferroelectric ceramics
The powder samples of [(Na0.5Bi0.5)0.94Ba0.06]1−xSrxTiO3 (NBBST) have been prepared successfully by a wet solid-phase method. The effects of Sr-do** on morphology, ferroelectric and dielectric properties of NBB...
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Article
Dielectric Properties of Sr-Doped Na0.5Bi0.5TiO3–Ba(1–x)Sr x Ti0.995Zr0.005O3 Ceramics Synthesized by Wet Solid-State Method
New dielectric composite ceramics Na0.5Bi0.5TiO3–Ba(1–x)Sr x Ti0.995Zr0.005O3 (NBT–BSTZ) ( x= 0.05, 0.1, 0.2, 0.3) have been fabricated by the wet solid-state route. The effect o...
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Article
Open AccessAuthor Correction: Metabolic Biomarkers for Prognostic Prediction of Pre-diabetes: results from a longitudinal cohort study
A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper.
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Article
Open AccessMetabolic Biomarkers for Prognostic Prediction of Pre-diabetes: results from a longitudinal cohort study
To investigate the metabolic biomarkers of predicting the transition from pre-diabetes (pre-DM) to normal glucose regulation (NGR) and diabetes (DM) in a longitudinal cohort study. 108 participants with pre-DM...
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Article
An application of target profiling analyses in the hepatotoxicity assessment of herbal medicines: comparative characteristic fingerprint and bile acid profiling of Senecio vulgaris L. and Senecio scandens Buch.-Ham
The toxicity assessment of herbal medicines is important for human health and appropriate utilization of these medicines. However, challenges have to be overcome because of the complexity of coexisting multipl...
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Article
UPLC-MS based metabolomics study on Senecio scandens and S. vulgaris: an approach for the differentiation of two Senecio herbs with similar morphology but different toxicity
Pyrrolizidine alkaloids show significant hepatotoxicity as they can bind to DNA or proteins after being activated in liver. Senecio vulgaris L., like many Compositae herbs containing pyrrolizidine alkaloids, was ...
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Article
The comparative pharmacokinetics of two pyrrolizidine alkaloids, senecionine and adonifoline, and their main metabolites in rats after intravenous and oral administration by UPLC/ESIMS
Pyrrolizidine alkaloids (PAs) are considered to be one of the most hepatotoxic groups of compounds of plant origin and are present in about 3% of the world’s flowering plants. Most PAs represent a considerable...
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Article
Simultaneous Quantification of Four Indole Alkaloids in Catharanthus roseus Cell Line C20hi by UPLC-MS
An ultra-performance liquid chromatography/mass spectrometry method to simultaneously quantify vindoline, catharanthine, serpentine and ajmalicine in Catharanthus roseus cell line C20hi is reported. Samples were ...
