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Upper Jurassic Rocks Beneath the Bristol Channel

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  1. Article

    Open Access

    Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine

    D-cycloserine is an antibiotic which targets sequential bacterial cell wall peptidoglycan biosynthesis enzymes: alanine racemase and D-alanine:D-alanine ligase. By a combination of structural, chemical and mec...

    Sarah Batson, Cesira de Chiara, Vita Majce, Adrian J. Lloyd… in Nature Communications (2017)

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  2. Article

    Open Access

    Reconstruction of diaminopimelic acid biosynthesis allows characterisation of Mycobacterium tuberculosis N-succinyl-L,L-diaminopimelic acid desuccinylase

    With the increased incidence of tuberculosis (TB) caused by Mycobacterium tuberculosis there is an urgent need for new and better anti-tubercular drugs. N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) is ...

    Veeraraghavan Usha, Adrian J. Lloyd, David I. Roper… in Scientific Reports (2016)

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  3. Article

    Open Access

    Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity

    The rapid rise of multi-drug-resistant bacteria is a global healthcare crisis, and new antibiotics are urgently required, especially those with modes of action that have low-resistance potential. One promising...

    Johannes Zuegg, Craig Muldoon, George Adamson, Declan McKeveney… in Nature Communications (2015)

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