4 Result(s)
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Article
Open AccessStructure-based design of stabilized recombinant influenza neuraminidase tetramers
Influenza virus neuraminidase (NA) is a major antiviral drug target and has recently reemerged as a key target of antibody-mediated protective immunity. Here we show that recombinant NAs across non-bat subtype...
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Article
Quadrivalent influenza nanoparticle vaccines induce broad protection
Influenza vaccines that confer broad and durable protection against diverse viral strains would have a major effect on global health, as they would lessen the need for annual vaccine reformulation and immuniza...
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Article
Open AccessA comprehensive influenza reporter virus panel for high-throughput deep profiling of neutralizing antibodies
Broadly neutralizing antibodies (bnAbs) have been developed as potential countermeasures for seasonal and pandemic influenza. Deep characterization of these bnAbs and polyclonal sera provides pivotal understan...
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Article
Prevalence of off-target effects in Drosophila RNA interference screens
The use of long double-stranded RNAs (dsRNAs) in Drosophila, where Dicer-mediated processing produces small RNAs inside cells, has been thought to reduce the probability of 'off-target effects' (OTEs). However, t...
