5 Result(s)

Article

A Phase I, First-in-Human Study of PRL3-zumab in Advanced, Refractory Solid Tumors and Hematological Malignancies

Phosphatase of regenerating liver-3 (PRL-3) is involved in cellular processes driving metastasis, cell proliferation, invasion, motility and survival. It has been shown to be upregulated and overexpressed in c...

Cheng E. Chee, Melissa Ooi, Soo-Chin Lee, Raghav Sundar, Valerie Heong… in Targeted Oncology (2023)

Article

Author Correction: PRL3 induces polyploid giant cancer cells eliminated by PRL3-zumab to reduce tumor relapse

Min Thura, Zu Ye, Abdul Qader Al-Aidaroos, Qiancheng **ong… in Communications Biology (2021)

Article

Author Correction: PRL3-zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoprotein

Min Thura, Abdul Qader Al-Aidaroos, Abhishek Gupta, Cheng Ean Chee… in Nature Communications (2021)

Article

PRL3 induces polyploid giant cancer cells eliminated by PRL3-zumab to reduce tumor relapse

PRL3, a unique oncotarget, is specifically overexpressed in 80.6% of cancers. In 2003, we reported that PRL3 promotes cell migration, invasion, and metastasis. Herein, firstly, we show that PRL3 induces Polypl...

Min Thura, Zu Ye, Abdul Qader Al-Aidaroos, Qiancheng **ong… in Communications Biology (2021)

Article

PRL3-zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoprotein

Tumor-specific antibody drugs can serve as cancer therapy with minimal side effects. A humanized antibody, PRL3-zumab, specifically binds to an intracellular oncogenic phosphatase PRL3, which is frequently exp...

Min Thura, Abdul Qader Al-Aidaroos, Abhishek Gupta, Cheng Ean Chee… in Nature Communications (2019)