7 Result(s)

Article

35th Annual Meeting of the European Association for the Study of Diabetes

A. Melander, J. Olsson, G. Lindberg, A. Salzman, T. Howard, P. Stang… in Diabetologia (1999)

Article

Quantification of beta-cell function during IVGTT in Type II and non-diabetic subjects: assessment of insulin secretion by mathematical methods

We compared four methods to assess their accuracy in measuring insulin secretion during an intravenous glucose tolerance test in patients with Type II (non-insulin-dependent) diabetes mellitus and with varyin...

L. L. Kjems, A. Vølund, S. Madsbad in Diabetologia (2001)

Article

Within-patient variation of the pharmacokinetics of subcutaneously injected biphasic insulin aspart as assessed by compartmental modelling

Pharmacokinetics of s.c. administered insulin preparations have been widely studied, mostly using descriptive measures such as AUC, time to peak, or the peak plasma concentration. Several compartmental modelli...

W. H. O. Clausen, A. De Gaetano, A. Vølund in Diabetologia (2006)

Article

Near normalisation of blood glucose improves the potentiating effect of GLP-1 on glucose-induced insulin secretion in patients with type 2 diabetes

The ability of glucagon-like peptide-1 (GLP-1) to enhance beta cell responsiveness to i.v. glucose is impaired in patients with type 2 diabetes mellitus compared with healthy individuals. We investigated wheth...

P. V. Højberg, M. Zander, T. Vilsbøll, F. K. Knop, T. Krarup, A. Vølund… in Diabetologia (2008)

Article

The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men

We studied the physiological, metabolic and hormonal mechanisms underlying the elevated risk of type 2 diabetes in carriers of TCF7L2 gene.

K. Pilgaard, C. B. Jensen, J. H. Schou, V. Lyssenko, L. Wegner, C. Brøns… in Diabetologia (2009)

Article

Steroid-induced insulin resistance and impaired glucose tolerance are both associated with a progressive decline of incretin effect in first-degree relatives of patients with type 2 diabetes

The aim of this study was to evaluate the separate impact of insulin resistance and impaired glucose tolerance (IGT) on the incretin effect.

D. H. Jensen, K. Aaboe, J. E. Henriksen, A. Vølund, J. J. Holst, S. Madsbad… in Diabetologia (2012)