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Article
Towards the development of a bioartificial pancreas: Immunoisolation and NMR monitoring of mouse insulinomas
A promising method for diabetes treatment is the implantation of immunoisolated cells secreting insulin in response to glucose. Cell availability limits the application of this approach at a medically-relevant...
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Article
Cultivation of recombinant, insulin-secreting AtT-20 cells as free and entrapped spheroids
Animal cells from endocrine glands have potential applications in bioprocessing, for the production of hormones, enzymes, possibly also recombinant proteins, and in tissue engineering, for the development of i...
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Article
Multiple episodes of induced secretion of human growth hormone from recombinant AtT-20 cells
Recombinant AtT-20 cells expressing human growth hormone (hGH) secreted the hormone at a constant, basal rate of 0.3–0.5 ng/105 cells-hour when exposed to medium without secretagogues. When triggered with 8 bromo...