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  1. No Access

    Article

    Towards the development of a bioartificial pancreas: Immunoisolation and NMR monitoring of mouse insulinomas

    A promising method for diabetes treatment is the implantation of immunoisolated cells secreting insulin in response to glucose. Cell availability limits the application of this approach at a medically-relevant...

    A. Sambanis, K. K. Papas, P. C. Flanders, R. C. Long Jr., H. Kang… in Cytotechnology (1994)

  2. No Access

    Article

    Cultivation of recombinant, insulin-secreting AtT-20 cells as free and entrapped spheroids

    Animal cells from endocrine glands have potential applications in bioprocessing, for the production of hormones, enzymes, possibly also recombinant proteins, and in tissue engineering, for the development of i...

    K. K. Papas, I. Constantinidis, A. Sambanis in Cytotechnology (1993)

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    Chapter

    Use of regulated secretion in protein production from animal cells: An overview

    Traditional industrial cell culture processes require extensive downstream product refining due to low product titer and purity in the spent growth medium. A controlled secretion process incorporating cells de...

    G. E. Grampp, A. Sambanis, G. N. Stephanopoulos in Modern Biochemical Engineering (1992)

  4. No Access

    Article

    Multiple episodes of induced secretion of human growth hormone from recombinant AtT-20 cells

    Recombinant AtT-20 cells expressing human growth hormone (hGH) secreted the hormone at a constant, basal rate of 0.3–0.5 ng/105 cells-hour when exposed to medium without secretagogues. When triggered with 8 bromo...

    A. Sambanis, Gregory Stephanopoulos, H. F. Lodish in Cytotechnology (1990)