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Article
Open AccessPaclitaxel and CYC3, an aurora kinase A inhibitor, synergise in pancreatic cancer cells but not bone marrow precursor cells
Amplification of aurora kinase A (AK-A) overrides the mitotic spindle assembly checkpoint, inducing resistance to taxanes. RNA interference targeting AK-A in human pancreatic cancer cell lines enhanced taxane ...
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Article
Breeding systems and continuing evolution in the endemic Sorbus taxa on Arran
The Arran whitebeams Sorbus arranensis and S. pseudofennica are two endemic woody plant taxa that have evolved on Arran through hybridisation. S. arranensis is a triploid hybrid between the widespread diploid S. ...
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Article
Open AccessA prognostic index for operable, node-negative breast cancer
Clinical data and samples from patients diagnosed, more than 10 years previously, with operable node-negative breast cancer (participants in the Scottish Adjuvant Tamoxifen trial), were revisited. Cases with t...
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Article
Increased revascularization efficacy after administration of an adenovirus encoding VEGF121
Adenovirus-mediated VEGF gene delivery is being evaluated in clinical trials as a treatment for patients with vascular diseases that stem from ischemia, such as diffuse coronary artery disease and peripheral v...
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Article
Open AccessA double-blind, randomised, controlled Phase II trial of Heliox28 gas mixture in lung cancer patients with dyspnoea on exertion
Helium has a low density and the potential of reducing the work of breathing and improving alveolar ventilation when replacing nitrogen in air. A Phase II, double-blind, randomised, prospective, controlled tri...
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Article
Functional imaging of Brain responses to repetitive sensory stimulation: Sources estimated from EEG and SPECT
This study examined the effect of modality of stimulation on two measures of cerebral function: (a) the scalp distribution of sensory evoked potentials and (b) the cerebral distribution of radiolabelled HMPAO....
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Article
Thoracic trident pigmentation in natural populations of Drosophila simulans: a comparison with D. melanogaster
By contrast with Drosophila melanogaster, wild living D. simulans adults generally do not exhibit a thoracic dark pigmentation with a trident shape. This trident however appears when development occurs at low tem...
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Article
Effect of low-dose bromocriptine in treatment of psychosis: The dopamine autoreceptor-stimulation strategy
Bromocriptine (0.5–6.0 mg/day) was administered to seven unmedicated chronic schizophrenic and two schizoaffective patients. Transient slight improvement was noted in four patients and marked improvement in on...