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Article
Open AccessAbsence of truncating BRIP1 mutations in chromosome 17q-linked hereditary prostate cancer families
In a genome-wide scan (GWS) of 175 multiplex prostate cancer (PCa) families from the University of Michigan Prostate Cancer Genetics Project (PCGP), linkage was observed to markers on chromosome 17q21–24, a re...
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Article
A genome-wide admixture scan for ancestry-linked genes predisposing to sarcoidosis in African-Americans
Genome-wide linkage and association studies have uncovered variants associated with sarcoidosis, a multiorgan granulomatous inflammatory disease. African ancestry may influence disease pathogenesis, as African...
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Article
Association of ANXA11 genetic variation with sarcoidosis in African Americans and European Americans
A recent genome-wide association study in a German population and two subsequent studies in European populations found that a non-synonymous single-nucleotide polymorphism (SNP), rs1049550, within the annexin A11
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Article
Polygenic risk assessment reveals pleiotropy between sarcoidosis and inflammatory disorders in the context of genetic ancestry
Sarcoidosis is a complex disease of unknown etiology characterized by the presence of granulomatous inflammation. Though various immune system pathways have been implicated in disease, the relationship between...