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  1. Article

    Open Access

    A Population Pharmacokinetic Modelling Approach to Unravel the Complex Pharmacokinetics of Vincristine in Children

    Vincristine, a chemotherapeutic agent that extensively binds to β-tubulin, is commonly dosed at 1.4–2.0 mg/m2 capped at 2 mg. For infants, doses vary from 0.025–0.05 mg/kg or 50–80% of the mg/m2 dose. However, ev...

    A. Laura Nijstad, Wan-Yu Chu, Evelien de Vos-Kerkhof… in Pharmaceutical Research (2022)

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