20 Result(s)

Article

Elevated mRNA expression of CHAC1 splicing variants is associated with poor outcome for breast and ovarian cancer patients

The role of CHAC1 (cation transport regulator-like protein 1), a recently identified component of the unfolded protein response (UPR) pathway, in gynaecological cancers has not yet been characterised. Now, thi...

G Goebel, R Berger, A M Strasak, D Egle, E Müller-Holzner… in British Journal of Cancer (2012)

Article

The treatment of early breast cancer in women over the age of 70

One third of all breast cancers are diagnosed in women aged 70 or over. Older women are a heterogeneous population who are under-represented in clinical trials, and as a result uncertainty can exist as to what...

A Ring, M Reed, R Leonard, I Kunkler, H Muss, H Wildiers… in British Journal of Cancer (2011)

Article

Idiopathic venous thromboembolic disease is associated with a poorer prognosis from subsequent malignancy

We carried out a retrospective study of prognosis in Scottish patients diagnosed with cancer within 5 years after a venous thromboembolism (VTE).

A Jones, D L Stockton, A J Simpson, J T Murchison in British Journal of Cancer (2009)

Article

Waiting times for systemic cancer therapy in the United Kingdom in 2006

This audit was conducted to measure waiting times for systemic cancer therapy across the United Kingdom. All patients, aged 16 years or older, commencing their first course of systemic therapy between 13 Novem...

M V Williams, K J Drinkwater, A Jones, B O'Sullivan, D Tait in British Journal of Cancer (2008)

Article

Medical student teaching in the UK: how well are newly qualified doctors prepared for their role caring for patients with cancer in hospital?

A number of studies have identified problems with undergraduate oncology teaching. We have investigated how well prepared newly qualified doctors (first foundation year, or FY1 doctors) are for treating patien...

J Cave, K Woolf, J Dacre, H W W Potts, A Jones in British Journal of Cancer (2007)

Article

Vinorelbine alternating oral and intravenous plus epirubicin in first-line therapy of metastatic breast cancer: results of a multicentre phase II study

The combination of intravenous (i.v.) vinorelbine and epirubicin is highly active in the treatment of metastatic breast cancer (MBC). In an effort to improve patient convenience, we investigated a regimen alte...

D Serin, M Verrill, A Jones, T Delozier, R Coleman… in British Journal of Cancer (2005)

Article

Phase I trial of intravesical Suramin in recurrent superficial transitional cell bladder carcinoma

Suramin is an antitrypanosomal agent with antineoplastic activity, but with serious systemic side effects. We administered Suramin intravesically to determine a concentration with low toxicity but with evidenc...

J J Ord, E Streeter, A Jones, K Le Monnier, D Cranston, J Crew… in British Journal of Cancer (2005)

Article

Cooperative stimulation of vascular endothelial growth factor expression by hypoxia and reactive oxygen species: the effect of targeting vascular endothelial growth factor and oxidative stress in an orthotopic xenograft model of bladder carcinoma

Elevated thymidine phosphorylase has been shown to correlate with increased angiogenesis and poor prognosis in many cancers including transitional cell carcinoma of the bladder. In vitro studies have demonstrated...

N S Brown, E H Streeter, A Jones, A L Harris, R Bicknell in British Journal of Cancer (2005)

Article

Trends in postoperative radiotherapy delay and the effect on survival in breast cancer patients treated with conservation surgery

The adequate timing of adjuvant radiotherapy (RT) in breast cancer has become a subject of increasing interest in recent years. A population-based study was undertaken to determine the influence of demographic...

J Stefoski Mikeljevic, R Haward, C Johnston, A Crellin… in British Journal of Cancer (2004)

Article

Block sequential adriamycin CMF – optimal non-myeloablative chemotherapy for high risk adjuvant breast cancer?

After the publication of the 10-year survival data from Milan on the adjuvant use of the block sequential regimen consisting of four cycles of adriamycin followed by eight cycles of intravenous CMF, many centr...

D A Cameron, A Anderson, E Toy, T R J Evans, J H Le Vay… in British Journal of Cancer (2002)

Article

Human bladder cancer invasion model using rat bladder in vitro and its use to test mechanisms and therapeutic inhibitors of invasion

As well as being a passive support, the extracellular matrix also regulates key biological processes such as invasion, differentiation and angiogenesis. We have therefore developed an in vitro model of bladder...

C Fujiyama, A Jones, S Fuggle, R Bicknell, D Cranston… in British Journal of Cancer (2001)

Article

Technical approaches for efficient printing of high-density microarrays and rapid, high-precision fluorescence analysis

D. Pinkel, G. Hamilton, A. Jones, D. Davy, M. Zorn, R. Segraves… in Nature Genetics (1999)