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Article
Open AccessOutreach, Screening, and Randomization of APOE ε4 Carriers into an Alzheimer’s Prevention Trial: A global Perspective from the API Generation Program
Alzheimer’s disease (AD) prevention trials require a large outreach and screening funnel to identify cognitively unimpaired adults who meet the study’s inclusion criteria, such as certain clinical or demograph...
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Article
Frakturfolge Typ 2 des proximalen Humerus – klinische Ergebnisse nach endoprothetischer Therapie
Die chronisch verhakte Luxation des Glenohumeralgelenks ist eine seltene, oft schmerzhafte Schulterpathologie, die mit ausgeprägten Bewegungseinschränkungen in der Schulter einhergehen kann. Bei Patienten im f...
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Article
Ist die Boileau-Klassifikation für Frakturfolgen des proximalen Humerus noch aktuell?
Die erfolgreiche Behandlung von Frakturfolgen am proximalen Humerus stellt im klinischen Alltag weiterhin eine große Herausforderung dar. In der vorliegenden Übersichtsarbeit wird die von Boileau im Jahr 2001 ...
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Article
Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy
Frameshift mutations in the DMD gene, encoding dystrophin, cause Duchenne muscular dystrophy (DMD), leading to terminal muscle and heart failure in patients. Somatic gene editing by sequence-specific nucleases of...
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Article
Acute myeloid leukemia in the elderly is characterized by a distinct genetic and epigenetic landscape
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Article
The target cell of transformation is distinct from the leukemia stem cell in murine CALM/AF10 leukemia models
The CALM/AF10 fusion gene is found in various hematological malignancies including acute myeloid leukemia (AML), T-cell acute lymphoblastic leukemia and malignant lymphoma. We have previously identified the leuke...
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Article
Detection of Entrainment Influences on Surface-Layer Measurements and Extension of Monin–Obukhov Similarity Theory
We present a method to detect influences of boundary-layer processes on surface-layer measurements, using statistics and spectra of surface-layer variables only. We validated our detection method with boundary...
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Article
Open AccessFAT1 expression and mutations in adult acute lymphoblastic leukemia
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Article
The intraoperative use of ultrasound facilitates significantly the arthroscopic debridement of calcific rotator cuff tendinitis
During arthroscopy, the localization of calcific deposit in patients suffering from calcifying tendinitis can be demanding and time consuming, frequently using ionizing radiation. Intraoperative ultrasound has...
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Article
An unexpectedly low oscillator strength as the origin of the Fe xvii emission problem
Fluorescence of iron ions induced by an X-ray laser allows the relative oscillator strength for Fe xvii emission to be determined; it is found to differ by 3.6σ from the best quantum mechanical calculations, sugg...
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Article
A geostatistical approach to the field-scale pattern of heterotrophic soil CO2 emission using covariates
Soil heterotrophic respiration fluxes at field scale may exhibit a substantial spatial variability. The aim of this study was (1) to elucidate the role of soil temperature and different carbon fractions on het...
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Article
Inverse determination of heterotrophic soil respiration response to temperature and water content under field conditions
Heterotrophic soil respiration is an important flux within the global carbon cycle. Exact knowledge of the response functions for soil temperature and soil water content is crucial for a reliable prediction of...
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Article
Somatic mutations in acute promyelocytic leukemia (APL) identified by exome sequencing
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Article
Ultrasound guidance improves the accuracy of the acromioclavicular joint infiltration: a prospective randomized study
Degeneration of the acromioclavicular joint (AC) often causes impaired shoulder function and pain. Its infiltration results in reportedly beneficial short-term effects. Misplacement of infiltrations is observe...
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Article
Open AccessModulation of plasma complement by the initial dose of epirubicin/docetaxel therapy in breast cancer and its predictive value
Despite the widespread use of neoadjuvant chemotherapy in breast cancer patients, prediction of individual response to treatment remains an unsolved clinical problem. Particularly, administration of an ineffic...
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Article
Rotational and translational laxity after computer-navigated single- and double-bundle anterior cruciate ligament reconstruction
Based on biomechanical cadaver studies, anatomic double-bundle reconstruction of the anterior cruciate ligament (ACL) was introduced to achieve better stability in the knee, particularly in respect of rotatory...
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Article
Normal Spectral Emissivity of the Industrially Used Alloys NiCr20TiAl, Inconel 718, X2CrNiMo18-14-3, and Another Austenitic Steel at 684.5 nm
Normal spectral emissivity measurements at 684.5 nm for two steels and two nickel-based superalloys at the melting transition and in the molten state are reported in this study. The measurements were performed...
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Article
Accuracy of soil heat flux plate measurements in coarse substrates – Field measurements versus a laboratory test
The in-situ performance of heat flux plates within coarse porous substrates might be limited due to poor contact between plate and substrate. We tested this behaviour with a simple laboratory set-up. Two test ...
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Poster
Objective: One of the most powerful medications that have very broad aspects of clinical application are the selective serotonin reuptake inhibitors (SSRI). We use SSRI as a first choice agents in tr...
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Article
Bildgebende Diagnostik im Staging gynäkologischer Karzinome