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Open AccessAssociations with sub-optimal clinic attendance and reasons for missed appointments among heterosexual women and men living with HIV in London
Poor engagement in HIV care is associated with poorer health outcomes and increased mortality. Our survey examined experiential and circumstantial factors associated with clinic attendance among women (n = 250...
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Accuracy of co-morbidity data in patients undergoing abdominal wall hernia repair: a retrospective study
To determine the baseline accuracy, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of routinely collected co-morbidity data in patients undergoing abdominal wall ...
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Open Access37th International Symposium on Intensive Care and Emergency Medicine (part 2 of 3)
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Open AccessProceedings of the International Cancer Imaging Society (ICIS) 16th Annual Teaching Course
O1 Tumour heterogeneity: what does it mean?
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Open AccessImpact of school-based vegetable garden and physical activity coordinated health interventions on weight status and weight-related behaviors of ethnically diverse, low-income students: Study design and baseline data of the Texas, Grow! Eat! Go! (TGEG) cluster-randomized controlled trial
Coordinated, multi-component school-based interventions can improve health behaviors in children, as well as parents, and impact the weight status of students. By leveraging a unique collaboration between Texa...
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Subcortical and cortical morphological anomalies as an endophenotype in obsessive-compulsive disorder
Endophentoypes, quantifiable traits lying on the causal chain between a clinical phenotype and etiology, can be used to accelerate genomic discovery in obsessive-compulsive disorder (OCD). Here we identify the...
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Resistance prediction in AML: analysis of 4601 patients from MRC/NCRI, HOVON/SAKK, SWOG and MD Anderson Cancer Center
Therapeutic resistance remains the principal problem in acute myeloid leukemia (AML). We used area under receiver-operating characteristic curves (AUCs) to quantify our ability to predict therapeutic resistanc...
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The prognostic relevance of flt3 and npm1 mutations on older patients treated intensively or non-intensively: a study of 1312 patients in the UK NCRI AML16 trial
Although the prognostic impact of mutations of FLT3 and NPM1 have been extensively studied in younger patients with acute myeloid leukaemia, less is known in older patients whether treated intensively or non-inte...
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Intracranial hypotension with a sixth cranial nerve palsy subsequent to massive thoracic CSF hygroma: a rare complication of thoracic disc excision
Thoracic cerebrospinal fluid (CSF) hygroma is a rare and potentially devastating complication of the anterior thoracic approach to the spine. We present two cases in which this complication resulted in acute ...
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Fruit and vegetable intake and smoking cessation
In cohort studies, fruit and vegetable (F&V) intake is associated with lower cardiovascular diseases (CVDs). Former smokers often have a higher F&V intake than current smokers. If a high intake of F&V precedes...
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Open AccessRetrospective comparison study of warfarinised trauma patients and an age-matched control group of nonwarfarinised patients
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Open AccessIntegrative mRNA profiling comparing cultured primary cells with clinical samples reveals PLK1 and C20orf20 as therapeutic targets in cutaneous squamous cell carcinoma
Identifying therapeutic targets for cancer treatment relies on consistent changes within particular types or sub-types of malignancy. The ability to define either consistent changes or sub-types of malignancy ...
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Association between the frequency of fruit and vegetable consumption and cardiovascular disease in male smokers and non-smokers
Consumption of fruit and vegetables (F&V) is associated with a lower cardiovascular disease (CVD) risk. Smoking may affect the strength of this association. The objective of this study was to compare the relat...
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Plasma free fatty acid patterns and their relationship with CVD risk in a male middle-aged population
The role of individual fatty acids in the development of cardiovascular disease (CVD) is well established, but the effects of an overall pattern of fatty acids in CVD risk has yet to be elucidated. Circulating...
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Residual cardiovascular risk in treated hypertension and hyperlipidaemia: the PRIME Study
Although pharmacological treatments of hypertension and dyslipidaemia are both associated with a reduction in cardiovascular risk, little is known about the degree of cardiovascular risk remaining in treated i...
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Adipocytokines and the risk of coronary heart disease in healthy middle aged men: the PRIME Study
Adipokines play an important role in glucose, lipid and lipoprotein metabolisms, as well as in coagulation and inflammatory processes. So far, studies have evaluated the association of individual adipokines wi...
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Effects of the Val158Met catechol-O-methyltransferase polymorphism on cortical structure in children and adolescents
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Vocal fold paralysis following surgical ductal closure in extremely low birth weight infants: a case series of feeding and respiratory complications
Surgical closure of a patent ductus arteriosus (PDA) continues to be a frequent procedure among extremely preterm infants. Recent evidence indicates surgical closure is associated with worse outcomes than afte...
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Skeletal benefits from calcium supplementation are limited in children with calcium intakes near 800 mg daily
Calcium supplementation enhances bone mass accrual during administration, with a sustained benefit observed using milk-based calcium but not calcium salts. We tested the hypothesis that calcium from milk miner...
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The use of ultrasound as an aid in the diagnosis of giant cell arteritis: a pilot study comparing histological features with ultrasound findings
Aims We present our preliminary experience with the use of ultrasound in aiding the diagnosis of giant cell arteritis (GCA). Schmidt et alhave previously described a hypoechoic or ‘halo’ effect surrounding the wa...