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    Article

    Polygenic risk assessment reveals pleiotropy between sarcoidosis and inflammatory disorders in the context of genetic ancestry

    Sarcoidosis is a complex disease of unknown etiology characterized by the presence of granulomatous inflammation. Though various immune system pathways have been implicated in disease, the relationship between...

    C A Lareau, C F DeWeese, I Adrianto, C J Lessard, P M Gaffney in Genes & Immunity (2017)

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    Article

    Gene-based association identifies SPATA13-AS1 as a pharmacogenomic predictor of inhaled short-acting beta-agonist response in multiple population groups

    Inhaled short-acting beta-agonist (SABA) medication is commonly used in asthma patients to rapidly reverse airway obstruction and improve acute symptoms. We performed a genome-wide association study of SABA me...

    B Padhukasahasram, J J Yang, A M Levin, M Yang in The Pharmacogenomics Journal (2014)

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    Article

    Association of ANXA11 genetic variation with sarcoidosis in African Americans and European Americans

    A recent genome-wide association study in a German population and two subsequent studies in European populations found that a non-synonymous single-nucleotide polymorphism (SNP), rs1049550, within the annexin A11

    A M Levin, M C Iannuzzi, C G Montgomery, S Trudeau, I Datta, P McKeigue in Genes & Immunity (2013)

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    Article

    A genome-wide admixture scan for ancestry-linked genes predisposing to sarcoidosis in African-Americans

    Genome-wide linkage and association studies have uncovered variants associated with sarcoidosis, a multiorgan granulomatous inflammatory disease. African ancestry may influence disease pathogenesis, as African...

    B A Rybicki, A M Levin, P McKeigue, I Datta, C Gray-McGuire, M Colombo in Genes & Immunity (2011)