29 Result(s)
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Article
Effects of different light conditions on morphological, anatomical, photosynthetic and biochemical parameters of Cypripedium macranthos Sw
In this study, the morphological (plant height, leaf length and width, stem diameter and leaf number), anatomical (epidermal cell density and thickness, Stomatal length and width), photosynthetic (net photosyn...
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Open AccessTargeting the SOX2/CDP protein complex with a peptide suppresses the malignant progression of esophageal squamous cell carcinoma
Emerging evidence indicates that SOX2 is an oncogene for esophageal squamous cell carcinoma (ESCC). However, direct targeting of SOX2 is not feasible given that this transcription factor plays important roles ...
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Article
Open AccessCLASRP oncogene as a novel target for colorectal cancer
Clk4-associated serine/arginine-rich protein (CLASRP), an alternative splicing regulator, may be involved in the development and progression of cancer by regulating the activity of the CDC-like kinase (Clk) famil...
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Article
Open AccessA frog peptide provides new strategies for the intervention against skin wound healing
Amphibian derived pro-healing peptides as molecular probes might provide a promising strategy for development of drug candidates and elucidation of cellular and molecular mechanisms of skin wound healing. A no...
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Article
Correction to: Geographical, Sex, Age, and Seasonal Differences in Serum Manganese Status Among Chinese Adults with Hypertension
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Article
Geographical, Sex, Age, and Seasonal Differences in Serum Manganese Status Among Chinese Adults with Hypertension
Manganese (Mn) is an essential trace metal element required for optimal human health. However, few studies have assessed the Mn status in hypertensive patients, especially in China. Moreover, factors associate...
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Article
Open AccessRNF8 up-regulates AR/ARV7 action to contribute to advanced prostate cancer progression
Androgen receptor (AR) signaling drives prostate cancer (PC) progression. Androgen deprivation therapy (ADT) is temporally effective, whereas drug resistance inevitably develops. Abnormal expression of AR/ARV7...
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Article
Chemical composition, antimicrobial, and antioxidant cytotoxic activities of essential oil from Actinidia arguta
Chemical composition, antimicrobial, antioxidant, and cytotoxic properties of Actinidia arguta essential oil (AEO) were evaluated. Gas chromatography–mass spectrometry analysis identified 56 chemical compounds, w...
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Article
Analysis of primary metabolites of Morchella fruit bodies and mycelium based on widely targeted metabolomics
As a medicinal and edible homologous fungi, Morchella is rich in multiple metabolites. The metabolite is a kind of essential substance with active components. In this study, Morchella fruit bodies and mycelium we...
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Article
Open AccessSidt2 is a key protein in the autophagy-lysosomal degradation pathway and is essential for the maintenance of kidney structure and filtration function
The regulation and homeostasis of autophagy are essential for maintaining organ morphology and function. As a lysosomal membrane protein, the effect of Sidt2 on kidney structure and renal autophagy is still unkno...
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Article
Open AccessKindlin-2 in Sertoli cells is essential for testis development and male fertility in mice
Kindlin-2 is known to play important roles in the development of mesoderm-derived tissues including myocardium, smooth muscle, cartilage and blood vessels. However, nothing is known for the role of Kindlin-2 i...
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Open AccessTransglutaminase 2: a novel therapeutic target for idiopathic pulmonary fibrosis using selective small molecule inhibitors
This study investigates the effects of a site-directed TG2-selective inhibitor on the lung myofibroblast phenotype and ECM deposition to elucidate TG2 as a novel therapeutic target in idiopathic pulmonary fibr...
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Article
Open AccessFZD5 contributes to TNBC proliferation, DNA damage repair and stemness
Chemotherapy currently remains the standard treatment for triple-negative breast cancer (TNBC). However, TNBC frequently develop chemoresistance, which is responsible for cancer recurrence and distal metastasi...
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Article
Open AccessMacrophage-derived extracellular vesicles: diverse mediators of pathology and therapeutics in multiple diseases
Macrophages (Mφ) are primary innate immune cells that exhibit diverse functions in response to different pathogens or stimuli, and they are extensively involved in the pathology of various diseases. Extracellu...
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Antioxidant and anti-tumour activity of triterpenoid compounds isolated from Morchella mycelium
Triterpenoid compounds are important bioactivity materials. Morchella is an abundant medicinal fungi found worldwide. In this study, we optimised the isolation and purification of triterpenoid compounds from Morc...
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Article
Effects of oral florfenicol on intestinal structure, function and microbiota in mice
Many kinds of antibiotics have effects on intestinal structure and function. In the current experimental study, we evaluate the effect of oral florfenicol on intestinal barrier in mice. Thirty adult male mice ...
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Article
ACTN3 is associated with children’s physical fitness in Han Chinese
The ACTN3 gene locates on 11q13-q14 and encodes the α-actinin-3 protein, which is only expressed in human skeletal muscle and influenced muscle function and metabolism. The previous studies reported that SNP rs18...
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The Importance of Se-Related Genes in the Chondrocyte of Kashin–Beck Disease Revealed by Whole Genomic Microarray and Network Analysis
Kashin–Beck disease (KBD) is an endemic, chronic, and degenerative osteoarthropathy. Selenium (Se) deficiency plays important role in the pathogenesis of KBD. We aimed to screen Se-related gene from chondrocyt...
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Article
Open AccessCardiac fibrosis can be attenuated by blocking the activity of transglutaminase 2 using a selective small-molecule inhibitor
Cardiac fibrosis is implicit in all forms of heart disease but there are no effective treatments. In this report, we investigate the role of the multi-functional enzyme Transglutaminase 2 (TG2) in cardiac fibr...
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Article
Open AccessCytokine-induced killer cells as a feasible adoptive immunotherapy for the treatment of lung cancer
Most of the patients with lung cancer are diagnosed at advanced stage, and they often lose the opportunity of surgical therapy, most of whom fail to reach good prognosis after chemotherapy. Recently, a few cli...
