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Article
Effect of storage media on chondrocyte viability during cold storage of osteochondral dowels
Osteochondral allograft transplantation is a successfully proven method to repair articular cartilage defects and prevent the degenerative effects of osteoarthritis. The number of osteochondral transplantation...
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Article
3D printing technology and its combination with nanotechnology in bone tissue engineering
With the graying of the world’s population, the morbidity of age-related chronic degenerative bone diseases, such as osteoporosis and osteoarthritis, is increasing yearly, leading to an increased risk of bone ...
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Article
Compressive mechanical properties of vitrified porcine menisci are superior to frozen and similar to fresh porcine menisci
The common practice of freezing meniscal allograft tissue is limited due to the formation of damaging ice crystals. Vitrification, which eliminates the formation of damaging ice crystals, may allow the mechani...
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Article
Mechanical Properties of Fresh, Frozen and Vitrified Articular Cartilage
Osteochondral allograft transplantations are typically used to treat focal articular cartilage injuries where the damaged cartilage is replaced with fresh cadaveric donor grafts. Despite the notable success ra...
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Article
CircRNA7632 down-regulation alleviates endothelial cell dysfunction in Kawasaki disease via regulating IL-33 expression
Kawasaki disease (KD) is a form of idiopathic vasculitis frequently accompanied by coronary artery lesions, which involves endothelial dysfunction. Recent studies have demonstrated that circular RNAs (circRNAs...
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Article
Open AccessClinical and prognostic significance of perioperative change in red cell distribution width in patients with esophageal squamous cell carcinoma
Numerous studies have reported the prognostic significance of the red cell distribution width (RDW) in patients with esophageal squamous cell carcinoma (ESCC), but the relationship between the perioperative ch...
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Article
Plasmonic polydopamine-modified TiO2 nanotube substrates for surface-assisted laser desorption/ionization mass spectrometry imaging
Mass spectrometry imaging (MSI) has made the spatio-chemical characterization of a broad range of small-molecule metabolites within biological tissues possible. However, available matrix-assisted laser desorpt...
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Article
Open AccessImpact of posttransplant cyclophosphamide on the outcome of patients undergoing unrelated single-unit umbilical cord blood transplantation for pediatric acute leukemia
Umbilical cord blood transplantation (UCBT) from unrelated donors is one of the successful treatments for acute leukemia in childhood. The most frequent side effect of UCBT is peri-engraftment syndrome (PES), ...
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Article
Open AccessIntegrating Internet multisource big data to predict the occurrence and development of COVID-19 cryptic transmission
With the recent prevalence of COVID-19, cryptic transmission is worthy of attention and research. Early perception of the occurrence and development risk of cryptic transmission is an important part of control...
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Article
Open AccessCorrection to: Integrative analysis of metabolomics and proteomics reveals amino acid metabolism disorder in sepsis
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Article
Sulforaphane ameliorates non-alcoholic fatty liver disease in mice by promoting FGF21/FGFR1 signaling pathway
Most studies regarding the beneficial effect of sulforaphane (SFN) on non-alcoholic fatty liver disease (NAFLD) have focused on nuclear factor E2-related factor 2 (Nrf2). But the molecular mechanisms underlyin...
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Article
Open AccessIntegrative analysis of metabolomics and proteomics reveals amino acid metabolism disorder in sepsis
Sepsis is defined as a systemic inflammatory response to microbial infections with multiple organ dysfunction. This study analysed untargeted metabolomics combined with proteomics of serum from patients with s...
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Article
The effect of cryoprotectant vehicle solution on cartilage cell viability following vitrification
Osteochondral allografts are often used to repair large articular cartilage defects to prevent or delay the onset of osteoarthritis. This approach is limited by the timely acquisition and use of allograft tiss...
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Article
Recent developments of infrared photodetectors with low-dimensional inorganic nanostructures
Low-dimensional inorganic nanostructures such as quantum dots as well as one- and two-dimensional nanostructures are widely studied and already used in high-performance infrared photodetectors. These structure...
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Article
Programmed albumin nanoparticles regulate immunosuppressive pivot to potentiate checkpoint blockade cancer immunotherapy
The therapeutic efficacy of programmed cell death protein 1/programmed cell death-ligand 1 (PD-1/PD-L1) blockade immunotherapy is extremely dampened by complex immunosuppressive mechanisms including regulatory...
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Article
Directional design and synthesis of high-yield hollow Fe-MFI zeolite encapsulating ultra-small Fe2O3 nanoparticles by using mother liquid
How to directionally design the hollow zeolite via a green route is of great significance. Here, we successfully synthesized the hollow Fe-silicate-1 encapsulated ultra-small Fe2O3 nanoparticles (2.5 nm) with hig...
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Article
Inhibition of AXL enhances chemosensitivity of human ovarian cancer cells to cisplatin via decreasing glycolysis
Anexelekto (AXL), a member of the TYRO3-AXL-MER (TAM) family of receptor tyrosine kinases (RTK), is overexpressed in varieties of tumor tissues and promotes tumor development by regulating cell proliferation, ...
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Article
Open AccessVitrification of particulated articular cartilage via calculated protocols
Preserving viable articular cartilage is a promising approach to address the shortage of graft tissue and enable the clinical repair of articular cartilage defects in articulating joints, such as the knee, ank...
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Article
Oxidised Low-Density Lipoprotein and Its Receptor-Mediated Endothelial Dysfunction Are Associated with Coronary Artery Lesions in Kawasaki Disease
The study aimed to investigate the role of oxidised low-density lipoprotein (oxLDL)/lectin-like-oxLDL receptor-1 (LOX-1) in coronary artery lesions (CALs) in Kawasaki disease (KD) and of plasma oxLDL concentra...
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Article
Nanoparticle-immersed paper imprinting mass spectrometry imaging reveals uptake and translocation mechanism of pesticides in plants
Design and discovery of carrier-mediated modified pesticides are vital for reducing pesticide dosage and increasing utilization, yet it remains a great challenge due to limited insights into plant translocatio...