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Article
Inflammation-Responsive Mesoporous Silica Nanoparticles with Synergistic Anti-inflammatory and Joint Protection Effects for Rheumatoid Arthritis Treatment
Joint destruction is a major burden and an unsolved problem in rheumatoid arthritis (RA) patients. We designed an intra-articular mesoporous silica nanosystem (MSN-TP@PDA-GlcN) with anti-inflammatory and joint...
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Article
Open AccessThe Childbearing sense of coherence scale (CSOC-scale): development and validation
the salutogenic theory is essential to explain an individual’s ability to maintain health during the perinatal period. While previous studies mainly focused on the perspectives from a family-level orientation ...
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Article
Kv3.1 Interaction with UBR5 Is Required for Chronic Inflammatory Pain
Chronic inflammatory pain caused by neuronal hyperactivity is a common and refractory disease. Kv3.1, a member of the Kv3 family of voltage-dependent K+ channels, is a major determinant of the ability of neurons ...
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Article
Policy involvement and policy consistency identification of supportive policies for SMEs
The practice of supportive policies for small and medium-sized enterprises (SMEs) in Zhejiang Province during the post-epidemic period is of great importance in boosting economy, creating employment, and promo...
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Article
Open AccessInfluenza virus uses mGluR2 as an endocytic receptor to enter cells
Influenza virus infection is initiated by the attachment of the viral haemagglutinin (HA) protein to sialic acid receptors on the host cell surface. Most virus particles enter cells through clathrin-mediated e...
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Article
Open AccessEvaluation of the application potential of Bdellovibrio sp. YBD-1 isolated from Yak faeces
Studies on Bdellovibrio and like organisms (BALOs), obligate predatory bacteria, have highlighted the possibility of regulating bacteria and biofilms; however, yak-derived BALOs are yet to be reported. We aimed t...
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Article
Synthesis, preclinical, and initial clinical evaluation of integrin αVβ3 and gastrin-releasing peptide receptor (GRPR) dual-targeting radiotracer [68Ga]Ga-RGD-RM26-03
Integrin receptor αvβ3 and gastrin-releasing peptide receptor (GRPR) expression of tumors could be detected using PET imaging with radiolabeled Arg-Gly-Asp (RGD) and the antagonistic bombesin analog RM26, respect...
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Article
Family Dinner Frequency, Parent-Organised Informal Learning Activities, and Student Academic Performance: Evidence from Chinese Eighth-Grade Students
The factors that influence student academic performance have long been discussed by academics. However, to our knowledge, there are no data on the informal learning activities organised by parents. Therefore, ...
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Article
Obstructive sleep apnea (OSA) is associated with increased risk of early-onset sarcopenia and sarcopenic obesity: Results from NHANES 2015-2018
This study aims to estimate the prevalence of early-onset sarcopenia and sarcopenic obesity in the United States and its relative risk due to obstructive sleep apnea (OSA).
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Article
Tracking endogenous proteins based on RNA editing-mediated genetic code expansion
Protein labeling approaches are important to study proteins in living cells, and genome editing tools make it possible to tag endogenous proteins to address the concerns associated with overexpression. Here we...
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Article
Development of small-molecular-based radiotracers for PET imaging of PD-L1 expression and guiding the PD-L1 therapeutics
Programmed cell death protein ligand 1 (PD-L1) is a crucial biomarker for immunotherapy. However, nearly 70% of patients do not respond to PD-L1 immune checkpoint therapy. Accurate monitoring of PD-L1 expressi...
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Article
Open AccessComparatively analysing the postoperative optical performance of different intraocular lenses: a prospective observational study
Postoperative performance, including best corrected distance visual acuity (BCDVA) and optical metrics (from the OQAS and iTrace devices), was compared among 4 different intraocular lenses (IOLs).
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Article
Susceptibility assessment of earthquake-induced landslide by using back-propagation neural network in the Southwest mountainous area of China
Earthquake-induced landslides are destructive and hazardous geological disasters, and mountainous areas are prone to earthquakes. Therefore, it is essential to establish an earthquake-induced landslide suscept...
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Article
Open AccessDiversity and potential host-interactions of viruses inhabiting deep-sea seamount sediments
Seamounts are globally distributed across the oceans and form one of the major oceanic biomes. Here, we utilized combined analyses of bulk metagenome and virome to study viral communities in seamount sediments...
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Article
The prognosis and treatment of newly diagnosed bone metastasis of head and neck squamous cell cancer: an analysis of racial disparity
There is a lack of research investigating racial disparity in newly diagnosed head and neck squamous cell carcinoma with isolated bone metastases (HNSCC-BM). This study aims to investigate the clinical charact...
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Article
Open AccessStructural basis of Acinetobacter type IV pili targeting by an RNA virus
Acinetobacters pose a significant threat to human health, especially those with weakened immune systems. Type IV pili of acinetobacters play crucial roles in virulence and antibiotic resistance. Single-strande...
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Article
Open AccessA proof-of-concept study on bioorthogonal-based pretargeting and signal amplify radiotheranostic strategy
Radiotheranostics differs from the vast majority of other cancer therapies in its capacity for simultaneous imaging and therapy, and it is becoming more widely implemented. A balance between diagnostic and tre...
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Article
M6PR interacts with the HA2 subunit of influenza A virus to facilitate the fusion of viral and endosomal membranes
Influenza A virus (IAV) commandeers numerous host cellular factors for successful replication. However, very few host factors have been revealed to be involved in the fusion of viral envelope and late endosoma...
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Article
Multi-attribute quantum group decision-making method considering decision-makers’ risk attitude
In the process of group decision-making, different decision-makers have different risk attitudes. There are quantum entanglements among the opinions of decision-makers, influencing each other rather than being...
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Article
Successful remission induction of IgG4-related ophthalmic disease by obinutuzumab therapy: a retrospective study of 8 patients
To evaluate the therapeutic efficacy and safety of obinutuzumab in remission induction for IgG4-related ophthalmic disease (IgG4-ROD) patients.
