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Article
Open AccessPrevalence, clinical characteristics, and long-term outcomes of new diabetes diagnosis in elderly patients undergoing percutaneous coronary intervention
Previous studies have reported associations between newly diagnosed diabetes and poor outcomes after percutaneous coronary intervention (PCI), but there is limited data focusing on elderly patients (age ≥ 65)....
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Article
Open AccessType 2 Biomarkers and Their Clinical Implications in Bronchiectasis: A Prospective Cohort Study
Bronchiectasis is predominantly marked by neutrophilic inflammation. The relevance of type 2 biomarkers in disease severity and exacerbation risk is poorly understood. This study explores the clinical signific...
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Article
Global distribution and genetic characterization of blaOXA-positive plasmids in Escherichia coli
In recent years, the emergence of blaOXA-encoding Escherichia coli (E. coli) poses a significant threat to human health. Here, we systematically analyzed the global geographic distribution and genetic characteris...
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Article
Open AccessAttitudes Toward Mononormativity and Polyamorous Legal Rights in the US
Recent research shows an increase in polyamory and acceptance of polyamorous relationships. However, there is still limited research on broader attitudes toward monogamy and polyamory, particularly regarding l...
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Article
DeepBiome: A Phylogenetic Tree Informed Deep Neural Network for Microbiome Data Analysis
Evidence linking the microbiome to human health is rapidly growing. The microbiome profile has the potential as a novel predictive biomarker for many diseases. However, tables of bacterial counts are typically...
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Article
Open AccessNIR triggered polydopamine coated cerium dioxide nanozyme for ameliorating acute lung injury via enhanced ROS scavenging
Acute lung injury (ALI) is a life threatening disease in critically ill patients, and characterized by excessive reactive oxygen species (ROS) and inflammatory factors levels in the lung. Multiple evidences su...
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Article
Open AccessIdentification of an HLA-A*11:01-restricted neoepitope of mutant PIK3CA and its specific T cell receptors for cancer immunotherapy targeting hotspot driver mutations
Hotspot driver mutations presented by human leukocyte antigens might be recognized by anti-tumor T cells. Based on their advantages of tumor-specificity and immunogenicity, neoantigens derived from hotspot mut...
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Article
Analysis of binding and authentic virus-neutralizing activities of immune sera induced by various monkeypox virus antigens
Monkeypox cases continue to increase globally, and there is an urgent need to develop a highly effective vaccine against monkeypox. This study investigated the binding and authentic-virus neutralizing activiti...
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Article
Open AccessAssembly and comparative analysis of the complete mitochondrial genome of Brassica rapa var. Purpuraria
Purple flowering stalk (Brassica rapa var. purpuraria) is a widely cultivated plant with high nutritional and medicinal value and exhibiting strong adaptability during growing. Mitochondrial (mt) play important r...
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Article
A Variant of the Logistic Quantal Response Equilibrium to Select a Perfect Equilibrium
The concept of perfect equilibrium, formulated by Selten (Int J Game Theory 4:25–55, 1975), serves as an effective characterization of rationality in strategy perturbation. In our study, we propose a modified ...
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Article
Effects of Vitamin D Supplementation on Cognitive Outcomes: A Systematic Review and Meta-Analysis
Clinical studies examining the effects of vitamin D on cognition have reported inconsistent results. To date, no comprehensive study has examined this effect on the basis of sample characteristics or intervent...
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Article
Kidney medicine meets computer vision: a bibliometric analysis
Rapid advances in computer vision (CV) have the potential to facilitate the examination, diagnosis, and treatment of diseases of the kidney. The bibliometric study aims to explore the research landscape and ev...
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Article
Open AccessNatural evidence of coronaviral 2′-O-methyltransferase activity affecting viral pathogenesis via improved substrate RNA binding
Previous studies through targeted mutagenesis of K-D-K-E motif have demonstrated that 2′-O-MTase activity is essential for efficient viral replication and immune evasion. However, the K-D-K-E catalytic motif o...
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Article
Open AccessLongitudinal viral shedding and antibody response characteristics of men with acute infection of monkeypox virus: a prospective cohort study
Understanding of infection dynamics is important for public health measures against monkeypox virus (MPXV) infection. Herein, samples from multiple body sites and environmental fomites of 77 acute MPXV infecti...
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Article
Open AccessTranscriptome analysis of Gossypium hirsutum cultivar Zhongzhimian No.2 uncovers the gene regulatory networks involved in defense against Verticillium dahliae
Cotton is globally important crop. Verticillium wilt (VW), caused by Verticillium dahliae, is the most destructive disease in cotton, reducing yield and fiber quality by over 50% of cotton acreage. Breeding resis...
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Article
Open AccessStroke and frailty index: a two-sample Mendelian randomisation study
Previous observational studies have found an increased risk of frailty in patients with stroke. However, evidence of a causal relationship between stroke and frailty is scarce. The aim of this study was to inv...
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Article
Open AccessInsights into the biocontrol and plant growth promotion functions of Bacillus altitudinis strain KRS010 against Verticillium dahliae
Verticillium wilt, caused by the fungus Verticillium dahliae, is a soil-borne vascular fungal disease, which has caused great losses to cotton yield and quality worldwide. The strain KRS010 was isolated from the ...
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Article
Open AccessVentricular Netrin-1 deficiency leads to defective pyramidal decussation and mirror movement in mice
The corticospinal tract (CST) is the principal neural pathway responsible for conducting voluntary movement in the vertebrate nervous system. Netrin-1 is a well-known guidance molecule for midline crossing of ...
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Article
Open AccessLeaders of Peer Groups in Chinese Early Adolescents: The Roles of Social, Academic, and Psychological Characteristics in Group Leadership
Leadership in peer groups is an important issue in adolescent socioemotional development, yet it has received limited attention in research. This one-year longitudinal study examined peer group leadership and ...
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Article
Open AccessCigarette smoke-induced dysbiosis: comparative analysis of lung and intestinal microbiomes in COPD mice and patients
The impact of cigarette smoke (CS) on lung diseases and the role of microbiome dysbiosis in chronic obstructive pulmonary disease (COPD) have been previously reported; however, the relationships remain unclear.
