7,173 Result(s)
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Open AccessImproved methods for the mathematically controlled comparison of biochemical systems
The method of mathematically controlled comparison provides a structured approach for the comparison of alternative biochemical pathways with respect to selected functional effectiveness measures. Under this a...
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Open AccessA steady state analysis indicates that negative feedback regulation of PTP1B by Akt elicits bistability in insulin-stimulated GLUT4 translocation
The phenomenon of switch-like response to graded input signal is the theme involved in various signaling pathways in living systems. Positive feedback loops or double negative feedback loops embedded with nonl...
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Open AccessRegulatory role of E-NTPase/E-NTPDase in Ca2+/Mg2+ transport via gated channel
E-NTPase/E-NTPDase is activated by millimolar concentrations of Ca2+ or Mg2+ with a pH optimum of 7.5 for the hydrolysis of extracellular NTP and NDP. It has been generally accepted that E-NTPase/E-NTPDase plays ...
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Open AccessInvestigation of hydrophobic moment and hydrophobicity properties for transmembrane α-helices
Integral membrane proteins are the primary targets of novel drugs but are largely without solved structures. As a consequence, hydrophobic moment plot methodology is often used to identify putative transmembrane
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Open AccessWe still fail to account for Mendel's observations
The present article corrects common textbook accounts of Mendel's experiments by re-establishing what he wrote and how he accounted for his observations. It notes the long-established tests for the validity of...
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Open AccessCould a simple surgical intervention eliminate HIV infection?
Human Immunodeficiency Virus (HIV) infection is a dynamic interaction of the pathogen and the host uniquely defined by the preference of the pathogen for a major component of the immune defense of the host. Si...
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Open AccessA rational treatment of Mendelian genetics
The key to a rational treatment of elementary Mendelian genetics, specifically to an understanding of the origin of dominant and recessive traits, lies in the facts that: (1) alleles of genes encode polypeptid...
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Open AccessPriming nonlinear searches for pathway identification
Dense time series of metabolite concentrations or of the expression patterns of proteins may be available in the near future as a result of the rapid development of novel, high-throughput experimental techniqu...
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Open AccessA mathematical model for LH release in response to continuous and pulsatile exposure of gonadotrophs to GnRH
In a previous study, a model was developed to investigate the release of luteinizing hormone (LH) from pituitary cells in response to a short pulse of gonadotropin-releasing hormone (GnRH). The model included:...
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Open AccessProteomics computational analyses suggest that the carboxyl terminal glycoproteins of Bunyaviruses are class II viral fusion protein (beta-penetrenes)
The Bunyaviridae family of enveloped RNA viruses includes five genuses, orthobunyaviruses, hantaviruses, phleboviruses, nairoviruses and tospoviruses. It has not been determined which Bunyavirus protein mediat...
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Open AccessApplication of methods of identifying receptor binding models and analysis of parameters
Possible methods for distinguishing receptor binding models and analysing their parameters are considered.
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Open AccessMetabolic scaling: consensus or controversy?
The relationship between body mass (M) and standard metabolic rate (B) among living organisms remains controversial, though it is widely accepted that in many cases B is approximately proportional to the three...
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Open AccessSize control in growing yeast and mammalian cells
In a recent publication it was claimed that cultured mammalian cells, in contrast to yeasts, maintain a constant size distribution in the population without a size checkpoint. This inference may be challengeable.
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Open AccessHuman embryonal epithelial cells of the develo** small intestinal crypts can express the Hodgkin-cell associated antigen Ki-1 (CD30) in spontaneous abortions during the first trimester of gestation
Ki-1 (CD30) antigen expression is not found on peripheral blood cells but its expression can be induced in vitro on T and B lymphocytes by viruses and lectins. Expression of CD30 in normal tissues is very limi...
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Open AccessConstruction of predictive promoter models on the example of antibacterial response of human epithelial cells
Binding of a bacteria to a eukaryotic cell triggers a complex network of interactions in and between both cells. P. aeruginosa is a pathogen that causes acute and chronic lung infections by interacting with the p...
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Open AccessIn vitro bioassay as a predictor of in vivo response
There is a substantial discrepancy between in vitro and in vivo experiments. The purpose of the present work was development of a theoretical framework to enable improved prediction of in vivo response from in vi...
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Open AccessSingle cell studies of the cell cycle and some models
Analysis of growth and division often involves measurements made on cell populations, which tend to average data. The value of single cell analysis needs to be appreciated, and models based on findings from si...
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Open AccessPropagated repolarization of simulated action potentials in cardiac muscle and smooth muscle
Propagation of repolarization is a phenomenon that occurs in cardiac muscle. We wanted to test whether this phenomenon would also occur in our model of simulated action potentials (APs) of cardiac muscle (CM) ...
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Open AccessVolume-based non-continuum modeling of bone functional adaptation
Bone adapts to mechanical strain by rearranging the trabecular geometry and bone density. The common finite element methods used to simulate this adaptation have inconsistencies regarding material properties a...
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Open AccessHigh-Temperature unfolding of a trp-Cage mini-protein: a molecular dynamics simulation study
Trp cage is a recently-constructed fast-folding miniprotein. It consists of a short helix, a 3,10 helix and a C-terminal poly-proline that packs against a Trp in the alpha helix. It is known to fold within 4 ns.
