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Article
Nanodiamond: a promising metal-free nanoscale material in photocatalysis and electrocatalysis
Benefiting from its surface-rich functional groups, eco-friendliness, impressive electrochemical properties, excellent light absorption, structural tunability at the atomic/morphological level, and ultra-high ...
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Article
Open AccessSodium tanshinone IIA sulfonate protects vascular relaxation in ApoE-knockout mice by inhibiting the SYK-NLRP3 inflammasome-MMP2/9 pathway
Hyperlipidemia damages vascular wall and serves as a foundation for diseases such as atherosclerosis, hypertension and stiffness. The NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is ...
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Article
Distribution, risk evaluation, and source allocation of cesium and strontium in surface soil in a mining city
Radioactive nuclides cesium (Cs) and strontium (Sr) possess long half-lives, with 135Cs at approximately 2.3 million years and 87Sr at about 49 billion years. Their persistent accumulation can result in long-last...
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Article
Clinical features, disease progression, and nuclear imaging in ATXN2-related parkinsonism in a longitudinal cohort
Spinocerebellar ataxia 2 (SCA2) with a low range of CAG repeat expansion of ATXN2 gene can present with predominant or isolated parkinsonism that closely resembles Parkinson’s disease (PD). This study is aimed at...
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Article
Self-assemble construction of hetero-structured Co(OH)2/MXene aerogel toward Li–S batteries as a self-supported host and bifunctional catalyst
The shuttling diffusion of polysulfides is a bottleneck that seriously limits the performance of Li–S batteries. Purposeful construction of sulfur cathodes with reliable trap** ability of polysulfides is the...
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Article
Recent advances in glycerol valorization through electrocatalytic methods
The recent tremendous growth of biodiesel production from vegetable oils or waste fats has led to increased glycerol accumulation as a by-product of this process. This sparked attention towards glycerol use an...
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Article
Open AccessSusceptibility gene identification and risk evaluation model construction by transcriptome-wide association analysis for salt sensitivity of blood pressure
Salt sensitivity of blood pressure (SSBP) is an intermediate phenotype of hypertension and is a predictor of long-term cardiovascular events and death. However, the genetic structures of SSBP are uncertain, an...
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Article
In situ reprogramming of cardiac fibroblasts into cardiomyocytes in mouse heart with chemicals
Cardiomyocytes are terminal differentiated cells and have limited ability to proliferate or regenerate. Condition like myocardial infarction causes massive death of cardiomyocytes and is the leading cause of d...
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Article
Trametinib, an anti-tumor drug, promotes oligodendrocytes generation and myelin formation
Oligodendrocytes (OLs) are differentiated from oligodendrocyte precursor cells (OPCs) in the central nervous system (CNS). Demyelination is a common feature of many neurological diseases such as multiple scler...
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Article
Open AccessTrends in maternal and child health in China and its urban and rural areas from 1991 to 2020: a joinpoint regression model
The long-term trends in maternal and child health (MCH) in China and the national-level factors that may be associated with these changes have been poorly explored. This study aimed to assess trends in MCH ind...
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Article
The Role of Ferroptosis in Amyotrophic Lateral Sclerosis Treatment
Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disease with a challenging treatment landscape, due to its complex pathogenesis and limited availability of clinical drugs. Ferroptosis, an iron-...
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Article
One-step controlled electrodeposition nickel sulfides heterointerfaces favoring the desorption of hydroxyl groups for efficient hydrogen generation
The heterointerface engineering involving different components or phases represents a desirable strategy for enhancing the sluggish kinetics of hydrogen evolution reaction (HER). However, constructing desired ...
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Article
Suppression of lysosome metabolism-meditated GARP/TGF-β1 complexes specifically depletes regulatory T cells to inhibit breast cancer metastasis
Regulatory T cells (Tregs) prevent autoimmunity and contribute to cancer progression. They exert contact-dependent inhibition of immune cells through the production of active transforming growth factor-β1 (TGF...
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Article
Catalytic activity and mechanism of F- and Cl-doped graphene for peroxymonosulfate activation to remove tetracycline hydrochloride
Highly active catalysts with salt and acid/alkali resistance are desired in peroxymonosulfate (PMS) activation processes and marine environment applications. F- and Cl-doped graphene (F-GN and Cl-GN) were prep...
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Article
Spatial Variation of Aquifer Permeability in the North China Plain from Large Magnitude Earthquake Signals
Permeability changes induced by earthquakes have been studied widely. However, basic questions still remain: what are the spatial differences in permeability changes induced by far-field earthquakes? Is there ...
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Article
Open AccessCelastrol inhibits mouse B16-F10 melanoma cell survival by regulating the PI3K/AKT/mTOR signaling pathway and repressing HIF-1α expression
Melanoma, with its high degree of malignancy, stands as one of the most dangerous skin cancers and remains the primary cause of death from skin cancer. With studies demonstrating the potential of traditional C...
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Article
CircNSD1 promotes cardiac fibrosis through targeting the miR-429-3p/SULF1/Wnt/β-catenin signaling pathway
Cardiac fibrosis is a detrimental pathological process, which constitutes the key factor for adverse cardiac structural remodeling leading to heart failure and other critical conditions. Circular RNAs (circRNA...
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Article
A potent new-scaffold androgen receptor antagonist discovered on the basis of a MIEC-SVM model
Prostate cancer (PCa) is the second most prevalent malignancy among men worldwide. The aberrant activation of androgen receptor (AR) signaling has been recognized as a crucial oncogenic driver for PCa and AR a...
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Article
Open AccessComparative analysis of GoPro and digital cameras in head and neck flap harvesting surgery video documentation: an innovative and efficient method for surgical education
An urgent need exists for innovative surgical video recording techniques in head and neck reconstructive surgeries, particularly in low- and middle-income countries where a surge in surgical procedures necessi...
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Article
Research progress on gravity heat pipe technology to prevent spontaneous combustion in coal storage piles
During coal storage and transportation, spontaneous combustion occurs occasionally. Heat pipes, as new fire prevention technology, have been applied and explored in the prevention and control of spontaneous co...
