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Article
Open AccessIdentification of BGN positive fibroblasts as a driving factor for colorectal cancer and development of its related prognostic model combined with machine learning
Numerous studies have indicated that cancer-associated fibroblasts (CAFs) play a crucial role in the progression of colorectal cancer (CRC). However, there are still many unknowns regarding the exact role of C...
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Article
Open AccessMETTL14-mediated N6-methyladenosine modification of SOX4 mRNA inhibits tumor metastasis in colorectal cancer
Colorectal cancer (CRC) is one of the leading causes of tumor-related death worldwide, and its main cause of death is distant metastasis. Methyltransferase-like 14(METTL14), a major RNA N6-adenosine methyltran...
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Article
Open AccessLncRNA SATB2-AS1 inhibits tumor metastasis and affects the tumor immune cell microenvironment in colorectal cancer by regulating SATB2
Emerging studies suggest that long non-coding RNAs (lncRNAs) play crucial roles in colorectal cancer (CRC). Here, we report a lncRNA, SATB2-AS1, which is specifically expressed in colorectal tissue and is sign...
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Article
Open AccessPolymorphisms of TGFBR1, TLR4 are associated with prognosis of gastric cancer in a Chinese population
Helicobacter pylori (H. pylori)-induced gastric cancer is an intricate progression of immune response against H. pylori infection. IL-16, TGF-β1 and TLR4 pathways were the mediators involved in the immune respons...
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Article
Open AccessThe pro-metastasis effect of circANKS1B in breast cancer
Recent studies indicate that circular RNA (circRNA) plays a pivotal role in cancer progression. Here, we sought to investigate its role in breast cancer.
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Article
Open AccessThe long noncoding RNA SNHG1 regulates colorectal cancer cell growth through interactions with EZH2 and miR-154-5p
Mounting evidence demonstrates that long noncoding RNAs (lncRNAs) have critical roles during the initiation and progression of cancers. In this study, we report that the small nucleolar RNA host gene 1 (SNHG1)...
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Article
Circulating miR-148/152 family as potential biomarkers in hepatocellular carcinoma
Aberrant expressions of the miR-148/152 family (miR-148a, miR-148b, and miR-152) have been documented in many tumor tissues, including hepatocellular carcinoma (HCC). However, the expression pattern and clinic...
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Article
Associations of polymorphisms in microRNAs with female breast cancer risk in Chinese population
Polymorphisms in microRNA (miRNA) have been discussed to be associated with breast cancer risk; however, the conclusions were always inconsistent in different ethnicities. This case–control study enrolled 450 ...
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Article
The diplotype Fas −1377A/−670G as a genetic marker to predict a lower risk of breast cancer in Chinese women
This study was designed to reveal the effects of Fas and FasL polymorphisms of interest on breast cancer risk. A total of 439 patients with breast cancer and 439 controls were enrolled in this study. The genotype...
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Article
Systematic review and meta-analysis on vitamin D receptor polymorphisms and cancer risk
The vitamin D receptor (VDR) can influence cancer susceptibility through binding to vitamin D. However, the previous studies were contradictory. Therefore this meta-analysis was conducted to clarify the associ...