6 Result(s)
within
**uli Zu
Cancer Research
-
Article
Open AccessCellular function reinstitution of offspring red blood cells cloned from the sickle cell disease patient blood post CRISPR genome editing
Sickle cell disease (SCD) is a disorder of red blood cells (RBCs) expressing abnormal hemoglobin-S (HbS) due to genetic inheritance of homologous HbS gene. However, people with the sickle cell trait (SCT) carr...
-
Article
ALK phosphorylates SMAD4 on tyrosine to disable TGF-β tumour suppressor functions
Loss of TGF-β tumour suppressive response is a hallmark of human cancers. As a central player in TGF-β signal transduction, SMAD4 (also known as DPC4) is frequently mutated or deleted in gastrointestinal and p...
-
Article
Open AccessXPO1 expression worsens the prognosis of unfavorable DLBCL that can be effectively targeted by selinexor in the absence of mutant p53
The XPO1 inhibitor selinexor was recently approved in relapsed/refractory DLBCL patients but only demonstrated modest anti-DLBCL efficacy, prompting us to investigate the prognostic effect of XPO1 in DLBCL pat...
-
Article
Author Correction: ALK phosphorylates SMAD4 on tyrosine to disable TGF-β tumour suppressor functions
A Correction to this paper has been published: https://doi.org/10.1038/s41556-021-00638-5.
-
Article
Open AccessDetermining clinical course of diffuse large B-cell lymphoma using targeted transcriptome and machine learning algorithms
Multiple studies have demonstrated that diffuse large B-cell lymphoma (DLBCL) can be divided into subgroups based on their biology; however, these biological subgroups overlap clinically. Using machine learnin...
-
Article
Open AccessA novel role of lysophosphatidic acid (LPA) in human myeloma resistance to proteasome inhibitors
Lysophosphatidic acid (LPA) is a naturally occurring phospholipid that regulates cell proliferation, survival, and migration. However, its role on human multiple myeloma (MM) cells is largely unknown. In this ...
