11 Result(s)
within
**uhui Jiang
Life Sciences
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Article
RNAi screens identify HES4 as a regulator of redox balance supporting pyrimidine synthesis and tumor growth
NADH/NAD+ redox balance is pivotal for cellular metabolism. Systematic identification of NAD(H) redox regulators, although currently lacking, would help uncover unknown effectors critically implicated in the coor...
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Article
Open AccessGFAT1-linked TAB1 glutamylation sustains p38 MAPK activation and promotes lung cancer cell survival under glucose starvation
Reprogrammed cell metabolism is deemed as one of the hallmarks of cancer. Hexosamine biosynthesis pathway (HBP) acts as an “energy sensor” in cells to regulate metabolic fluxes. Glutamine-fructose-6-phosphate ...
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The alternative activity of nuclear PHGDH contributes to tumour growth under nutrient stress
The multifunctional roles of metabolic enzymes allow for the integration of multiple signals to precisely transduce external stimuli into cell fate decisions. Elevation of 3-phosphoglycerate dehydrogenase (PHG...
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Author Correction: Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation
In the version of this Article originally published, the authors mistakenly used the same images for three different time points in Fig. 2d: images for 24 h post-IR WT were also used for 0 h post-IR WT (top ro...
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Article
O-GlcNAcylation of fumarase maintains tumour growth under glucose deficiency
Chromatin-associated fumarase (FH) affects histone methylation via its metabolic activity. However, whether this effect is involved in gene transcription remains to be clarified. In this study, we show that un...
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Correction: Corrigendum: A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation
Nature Cell Biology 18, 561–571 (2016); published online 18 April 2016; corrected after print 27 April 2016 In the version of this Article originally published, the affiliations for Gilbert Cote, Hongxia Wang ...
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Article
A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation
Dietary fructose is primarily metabolized in the liver. Here we demonstrate that, compared with normal hepatocytes, hepatocellular carcinoma (HCC) cells markedly reduce the rate of fructose metabolism and the ...
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Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation
Histone methylation regulates DNA repair. However, the mechanisms that underlie the regulation of histone methylation during this repair remain to be further defined. Here, we show that exposure to ionizing ra...
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Article
PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus
Ras plays a pivotal role in many cellular activities, and its subcellular compartmentalization provides spatial and temporal selectivity. Here we report a mode of spatial regulation of Ras signaling in the Gol...
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Biophysical studies on the differentiation of human CD14+ monocytes into dendritic cells
Dendritic cells (DCs), which are the most efficient antigen-presenting cells (APCs) currently known, can be derived from CD14+ monocytes (DC predecessor cells) in vitro. Immature DCs actively take up antigens and...
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TFAR19 gene changes the biophysical properties of murine erythroleukemia cells
TFAR19 is a novel apoptosis-related gene and can accelerate cell apoptosis in the presence of apoptosis inducements. Here, we studied the effects of TFAR19 on some biophysical properties of mouse erythroleukem...
