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Article
Open AccessOptimal antiplatelet therapy after revascularization of left subclavian artery during TEVAR
Thoracic endovascular aortic repair (TEVAR) is a minimally invasive technique used to treat type B aortic dissections. Left subclavian artery (LSA) reconstruction is required when treating patients with involv...
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Article
Auto-parametric resonance of a continuous-beam-bridge model under two-point periodic excitation: an experimental investigation and stability analysis
The auto-parametric resonance of a continuous-beam bridge model subjected to a two-point periodic excitation is experimentally and numerically investigated in this study. An auto-parametric resonance experimen...
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Article
Effects of Soil Physicochemical Properties on Maize, Wheat, and Soybean Yields in Maize-Wheat and Maize-Soybean Intercrop** Systems in China: a Meta-analysis
Intercrop** has demonstrated its potential to boost crop yields and optimize land utilization in numerous instances. Yet, the specific mechanisms underlying the enhancement of intercropped plants’ relationsh...
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Article
Open AccessFibroblast Growth Factor 21 Relieves Lipopolysaccharide-Induced Acute Lung Injury by Suppressing JAK2/STAT3 Signaling Pathway
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a life‐threatening disease without an effective drug at present. Fibroblast growth factor 21 (FGF21) was reported to be protective against ...
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Article
Open AccessSurgical treatment for right-side aortic arch concomitant with Kommerell’s diverticulum: techniques selection and follow-up results
Right-side aortic arch concomitant with Kommerell’s diverticulum (KD) is a rare and complex ailment, and there is no consensus on the optimal strategy to deal with this congenital anomaly. We retrospectively a...
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Article
Open AccessEfficacy and safety of thrombopoietin receptor agonists in solid tumors with chemotherapy-induced thrombocytopenia: a meta-analysis
To evaluate the efficacy and safety of thrombopoietin receptor agonists (TPO-RAs) in solid tumors with chemotherapy-induced thrombocytopenia (CIT).
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Article
Open AccessPredicting multiple linear stapler firings in double stapling technique with an MRI-based deep-learning model
Multiple linear stapler firings is a risk factor for anastomotic leakage (AL) in laparoscopic low anterior resection (LAR) using double stapling technique (DST) anastomosis. In this study, our objective was to...
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Article
Transient state flow and heat transfer performance over the flat tip of HP turbine
To study the flow and heat transfer performance over the flat tip of high pressure (HP) turbine under transient conditions more accurately, a dynamic boundary condition model from one stable operating state to...
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Article
Open AccessBiodegradable FePS3 nanoplatform for efficient treatment of osteosarcoma by combination of gene and NIR-II photothermal therapy
As a common tumor with high incidence, osteosarcoma possesses extremely poor prognosis and high mortality. Improving the survival of osteosarcoma patients is still a great challenge due to the precipice of adv...
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Article
A Review of Durable Flame-Retardant Fabrics by Finishing: Fabrication Strategies and Challenges
Fabrics with durable flame retardancy are of great importance for preventing potential fire threats in daily life. This review presents a comprehensive discussion of advances in durable flame-retardant fabrics...
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Article
Open AccessTargeting MFAP5 in cancer-associated fibroblasts sensitizes pancreatic cancer to PD-L1-based immunochemotherapy via remodeling the matrix
Highly desmoplastic and immunosuppressive tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC) contributes to tumor progression and resistance to current therapies. Clues targeting the notor...
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Article
Open AccessPolyamine metabolism patterns characterized tumor microenvironment, prognosis, and response to immunotherapy in colorectal cancer
Changes in Polyamine metabolism (PAM) have been shown to establish a suppressive tumor microenvironment (TME) and substantially influence the progression of cancer in the recent studies. However, newly emergin...
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Article
Open AccessExploring the role of pyroptosis in sha** the tumor microenvironment of colorectal cancer by bulk and single-cell RNA sequencing
Emerging studies have shown that pyroptosis plays a non-negligible role in the development and treatment of tumors. However, the mechanism of pyroptosis in colorectal cancer (CRC) remains still unclear. Theref...
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Article
Open AccessGenome-wide analysis of UDP-glycosyltransferases family and identification of UGT genes involved in abiotic stress and flavonol biosynthesis in Nicotiana tabacum
Uridine disphosphate (UDP) glycosyltransferases (UGTs) act upon a huge variety of highly diverse and complex substrates, such as phytohormones and specialized metabolites, to regulate plant growth, development...
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Article
Open AccessComparison of genetic impact on growth and wood traits between seedlings and clones from the same plus trees of Pinus koraiensis
To evaluate the relationships among clones and open pollinated families from the same plus trees and to select elite breeding materials, growth, and wood characteristics of 33-year-old Pinus koraiensis clones and...
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Article
Open AccessCirc-Ntrk2 acts as a miR-296-5p sponge to activate the TGF-β1/p38 MAPK pathway and promote pulmonary hypertension and vascular remodelling
Circular RNAs (circRNAs), a novel class of non-coding RNAs, play an important regulatory role in pulmonary arterial hypertension (PAH); however, the specific mechanism is rarely studied. In this study, we aime...
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Article
Open AccessRoles and mechanisms of tumour-infiltrating B cells in human cancer: a new force in immunotherapy
Immune checkpoint inhibitors (ICIs) targeting PD-1 or PD-L1 have emerged as a revolutionary treatment strategy for human cancer patients. However, as the response rate to ICI therapy varies widely among differ...
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Article
Open AccessGeographical origin of Plasmodium vivax in the Hainan Island, China: insights from mitochondrial genome
Hainan Province, China, has been an endemic region with high transmission of Plasmodium falciparum and Plasmodium vivax. Indigenous malaria caused by P. vivax was eliminated in Hainan in 2011, while imported viva...
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Article
Open AccessTargeting ubiquitin-specific protease 8 sensitizes anti-programmed death-ligand 1 immunotherapy of pancreatic cancer
Programmed death-1 (PD-1) and its ligand programmed death-ligand 1 (PD-L1) help tumor cells evade immune surveillance, and are regarded as important targets of anti-tumor immunotherapy. Post-translational modi...
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Article
Open AccessA preoperative magnetic resonance imaging-based model to predict biochemical failure after radical prostatectomy
To investigate if a magnetic resonance imaging (MRI)-based model reduced postoperative biochemical failure (BF) incidence in patients with prostate cancer (PCa). From June 2018 to January 2020, we retrospectiv...
