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Article
Discovery of a novel BTK inhibitor S-016 and identification of a new strategy for the treatment of lymphomas including BTK inhibitor-resistant lymphomas
Bruton’s tyrosine kinase (BTK) has emerged as a therapeutic target for B-cell malignancies, which is substantiated by the efficacy of various irreversible or reversible BTK inhibitors. However, on-target BTK m...
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Article
Analysis of destructive effect of Zn on carbon brick and way of Zn into carbon brick
The service life of a blast furnace depends largely on the degree of damage to the carbon brick in the hearth. Carbon brick and ramming material in the hearth of a 1780 m3 blast furnace after shutdown were sample...
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Article
Open AccessSphingomonas lacusdianchii sp. nov., an attached bacterium inhibited by metabolites from its symbiotic cyanobacterium
An alpha-proteobacterial strain JXJ CY 53 T was isolated from the cyanosphere of Microcystis sp. FACHB-905 (MF-905) collected from Lake Dianchi, China. JXJ CY 53 T was observed to be an aerobic, Gram-stain-negati...
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Article
Open AccessThe correlation between tumor radiological features and spread through air spaces in peripheral stage IA lung adenocarcinoma: a propensity score-matched analysis
The consolidation tumor ratio (CTR) is a predictor of invasiveness in peripheral T1N0M0 lung adenocarcinoma. However, its association with spread through air spaces (STAS) remains largely unexplored. We aimed ...
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Article
Whole-brain in vivo base editing reverses behavioral changes in Mef2c-mutant mice
Whole-brain genome editing to correct single-base mutations and reduce or reverse behavioral changes in animal models of autism spectrum disorder (ASD) has not yet been achieved. We developed an apolipoprotein...
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Chapter and Conference Paper
Efficient Numerical Simulation Grid System for Massive Bottom Water Reservoir
The scheme of numerical simulation grid directly affects computational accuracy, speed and convergence. For massive bottom water reservoir, there is no stable restraining barrier inside, so gravity differentia...
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Article
Dynamics Analysis of the Double Push Rod Limb-Leg Mechanism with Clearance Joint
The research object of this paper is a double push rod limb-leg mechanism with clearance joints. To begin, a dynamic model of the double push rod limb-leg mechanism with clearance joints is developed. Then, th...
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Article
GABAergic Neurons in the Nucleus Accumbens are Involved in the General Anesthesia Effect of Propofol
The mechanism underlying the hypnosis effect of propofol is still not fully understood. In essence, the nucleus accumbens (NAc) is crucial for regulating wakefulness and may be directly engaged in the principl...
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Article
DHX9/DNA-tandem repeat-dependent downregulation of ciRNA-Fmn1 in the dorsal horn is required for neuropathic pain
Circular RNAs (ciRNAs) are emerging as new players in the regulation of gene expression. However, how ciRNAs are involved in neuropathic pain is poorly understood. Here, we identify the nervous-tissue-specific ci...
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Article
Open AccessA longitudinal resource for population neuroscience of school-age children and adolescents in China
During the past decade, cognitive neuroscience has been calling for population diversity to address the challenge of validity and generalizability, ushering in a new era of population neuroscience. The develop...
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Article
Dipyridamole enhances the anti-cancer ability of aspirin against colorectal cancer by inducing apoptosis in an unfolded protein response-dependent manner
Available evidence indicates that dipyridamole enhances the anti-thrombotic effects of aspirin for the prevention of secondary strokes. Aspirin is a well-known non-steroid anti-inflammatory drug. This anti-inf...
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Article
Diagnostic value of myeloperoxidase and eosinophil cationic protein in nasal secretions for endotypes of chronic rhinosinusitis
To explore associations between inflammatory endotypes and clinical presentations in CRS. To investigate the value of secretions myeloperoxidase (MPO) and eosinophilic cationic protein (ECP) detections in the ...
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Article
Localized corrosion process of Al-Zn-Mg-Cu-Zr alloy: Transitions from pitting corrosion to intergranular corrosion
The localized corrosion mode and process dependence on ageing conditions for Al-7.82Zn-1.99Mg-2.41Cu-0.12Zr alloy were investigated. Intergranular corrosion (IGC) is the dominant corrosion mode for UA temper a...
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Article
Reducing nonlinear vibration of locally resonant plates via multi-frequency resonators
The nonlinear vibration reduction in locally resonant cantilever thin plate with multi-frequency periodically distributed resonators is investigated, considering the geometric nonlinearity of the plate. Based ...
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Article
Vibration reduction in a composite laminated cylindrical shell via embedded NiTiNOL-steel wire ropes
Embedded NiTiNOL-steel wire ropes are proposed as a nonlinear damper for a composite laminated cylindrical shell. Its dynamic responses to axial harmonic excitations are analyzed with a focus on vibration redu...
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Article
Open AccessSix immune-related promising biomarkers may promote hepatocellular carcinoma prognosis: a bioinformatics analysis and experimental validation
Abnormal miRNA and mRNA expression and dysregulated immune microenvironment have been found to frequently induce the progression of hepatocellular carcinoma (HCC) in recent reports. In particular, the immune-r...
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Article
Open AccessBiofouling characteristics of reverse osmosis membranes by disinfection-residual-bacteria post seven water disinfection techniques
Reverse osmosis (RO) is widely used in wastewater reclamation to alleviate the increasingly global water shortage. However, it has an inconvenient defect of biofouling. Some disinfection processes have been re...
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Article
Incremental value of PET primary lesion-based radiomics signature to conventional metabolic parameters and traditional risk factors for preoperative prediction of lymph node metastases in gastric cancer
Precise preoperative prediction of lymph node metastasis (LNM) is crucial for optimal diagnosis and treatment in patients with gastric cancer (GC), in which existing imaging methods have certain limitations. W...
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Article
Effects of oxygen content on gaseous and solid products during molten salt oxidation of cation exchange resins
Molten salt oxidation (MSO) is an advanced method for waste resins treatment; nevertheless, the research about gas product variations of resins under different stoichiometric air feed coefficient (α) is rare. ...
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Article
Open AccessSolar X-ray and EUV imager on board the FY-3E satellite
The solar X-ray and Extreme Ultraviolet Imager (X-EUVI), developed by the Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences (CIOMP), is the first space-based solar X-ray an...
