13 Result(s)

Article

Deep learning model for the prediction of all-cause mortality among long term care people in China: a prospective cohort study

This study aimed to develop a deep learning model to predict the risk stratification of all-cause death for older people with disability, providing guidance for long-term care plans. Based on the government-le...

Huai-Cheng Tan, Li-Jun Zeng, Shu-Juan Yang, Li-Sha Hou, **-Hui Wu… in Scientific Reports (2024)

Article

Endocytosis-mediated entry of a caterpillar effector into plants is countered by Jasmonate

Insects and pathogens release effectors into plant cells to weaken the host defense or immune response. While the imports of some bacterial and fungal effectors into plants have been previously characterized, ...

Zi-Wei Yan, Fang-Yan Chen, **an Zhang, Wen-Juan Cai, Chun-Yu Chen… in Nature Communications (2023)

Article

Camrelizumab combined with apatinib in patients with first-line platinum-resistant or PD-1 inhibitor resistant recurrent/metastatic nasopharyngeal carcinoma: a single-arm, phase 2 trial

Immunotherapy combined with antiangiogenic targeted therapy has improved the treatment of certain solid tumors, but effective regimens remain elusive for refractory recurrent/metastatic nasopharyngeal carcinom...

Li Yuan, Guo-Dong Jia, **ao-Fei Lv, Si-Yi **e, Shan-Shan Guo… in Nature Communications (2023)

Article

Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study o...

Jianxin Shi, Kouya Shiraishi, Jiyeon Choi, Keitaro Matsuo… in Nature Communications (2023)

Article

Author Correction: Identification of a differentiation-related prognostic nomogram based on single-cell RNA sequencing in clear cell renal cell carcinoma

Zhi-Nan **a, **g-Gen Wu, Wen-Hao Yao, Yu-Yang Meng, Wen-Gang Jian… in Scientific Reports (2023)

Article

Urinary miR-16-5p can be used as a potential marker of endocapillary hypercellularity in IgA nephropathy

The most prevalent primary glomerulonephritis and leading cause of end-stage renal disease worldwide is IgA nephropathy (IgAN). More and more studies are describing urinary microRNA (miRNA) as a non-invasive m...

Meng Zhang, Zhi-Yu Duan, Qiu-Yue Zhang, **e-Guan-Xuan Xu, Yan Zhang… in Scientific Reports (2023)

Article

Identification of a differentiation-related prognostic nomogram based on single-cell RNA sequencing in clear cell renal cell carcinoma

Renal cell carcinoma (RCC) is a kidney cancer that is originated from the lined proximal convoluted tubule, and its major histological subtype is clear cell RCC (ccRCC). This study aimed to retrospectively ana...

Zhi-Nan **a, **g-Gen Wu, Wen-Hao Yao, Yu-Yang Meng, Wen-Gang Jian… in Scientific Reports (2022)

Article

Molecular mechanism of agonism and inverse agonism in ghrelin receptor

Much effort has been invested in the investigation of the structural basis of G protein-coupled receptors (GPCRs) activation. Inverse agonists, which can inhibit GPCRs with constitutive activity, are considere...

Jiao Qin, Ye Cai, Zheng Xu, Qianqian Ming, Su-Yu Ji, Chao Wu… in Nature Communications (2022)

Article

Clofazimine broadly inhibits coronaviruses including SARS-CoV-2

The COVID-19 pandemic is the third outbreak this century of a zoonotic disease caused by a coronavirus, following the emergence of severe acute respiratory syndrome (SARS) in 2003¹ and Middle East respiratory syn...

Shuofeng Yuan, **n Yin, **angzhi Meng, Jasper Fuk-Woo Chan, Zi-Wei Ye, Laura Riva… in Nature (2021)

Article

Host and viral determinants for efficient SARS-CoV-2 infection of the human lung

Understanding the factors that contribute to efficient SARS-CoV-2 infection of human cells may provide insights on SARS-CoV-2 transmissibility and pathogenesis, and reveal targets of intervention. Here, we ana...

Hin Chu, Bingjie Hu, **ner Huang, Yue Chai, Dongyan Zhou… in Nature Communications (2021)

Article

Machine learning based early warning system enables accurate mortality risk prediction for COVID-19

Soaring cases of coronavirus disease (COVID-19) are pummeling the global health system. Overwhelmed health facilities have endeavored to mitigate the pandemic, but mortality of COVID-19 continues to increase. ...

Yue Gao, Guang-Yao Cai, Wei Fang, Hua-Yi Li, Si-Yuan Wang… in Nature Communications (2020)

Article

An aldo-keto reductase is responsible for Fusarium toxin-degrading activity in a soil Sphingomonas strain

Degradation of toxins by microorganisms is a promising approach for detoxification of agricultural products. Here, a bacterial strain, Sphingomonas S3-4, that has the ability to degrade the mycotoxin deoxynivalen...

Wei-Jie He, Limin Zhang, Shu-Yuan Yi, Xue-Ling Tang, Qing-Song Yuan… in Scientific Reports (2017)

Article

A CpG-methylation-based assay to predict survival in clear cell renal cell carcinoma

Clear cell renal cell carcinomas (ccRCCs) display divergent clinical behaviours. Molecular markers might improve risk stratification of ccRCC. Here we use, based on genome-wide CpG methylation profiling, a LAS...

**-Huan Wei, Ahmed Haddad, Kai-Jie Wu, Hong-Wei Zhao, Payal Kapur… in Nature Communications (2015)