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Article
MAMs and Mitochondrial Quality Control: Overview and Their Role in Alzheimer’s Disease
Alzheimer’s disease (AD) represents the most widespread neurodegenerative disorder, distinguished by a gradual onset and slow progression, presenting a substantial challenge to global public health. The mitoch...
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Article
Open AccessMining the interpretable prognostic features from pathological image of intrahepatic cholangiocarcinoma using multi-modal deep learning
The advances in deep learning-based pathological image analysis have invoked tremendous insights into cancer prognostication. Still, lack of interpretability remains a significant barrier to clinical application.
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Article
Acetylcytidine modification of Amotl1 by N-acetyltransferase 10 contributes to cardiac fibrotic expansion in mice after myocardial infarction
Cardiac fibrosis is a pathological scarring process that impairs cardiac function. N-acetyltransferase 10 (Nat10) is recently identified as the key enzyme for the N4-acetylcytidine (ac4C) modification of mRNAs...
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Article
Open AccessDeep learning model for the prediction of all-cause mortality among long term care people in China: a prospective cohort study
This study aimed to develop a deep learning model to predict the risk stratification of all-cause death for older people with disability, providing guidance for long-term care plans. Based on the government-le...
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Article
Open AccessSignal enhancement ratio of multi-phase contrast-enhanced MRI: an imaging biomarker for survival in pancreatic adenocarcinoma
To evaluate signal enhancement ratio (SER) for tissue characterization and prognosis stratification in pancreatic adenocarcinoma (PDAC), with quantitative histopathological analysis (QHA) as the reference stan...
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Article
Open AccessAge at lung cancer diagnosis in females versus males who never smoke by race and ethnicity
We characterized age at diagnosis and estimated sex differences for lung cancer and its histological subtypes among individuals who never smoke.
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Article
Clinical application of repetitive transcranial magnetic stimulation in improving functional impairments post-stroke: review of the current evidence and potential challenges
In recent years, the stroke incidence has been increasing year by year, and the related sequelae after stroke, such as cognitive impairment, motor dysfunction, and post-stroke depression, seriously affect the ...
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Article
RuCo alloy nanoparticles embedded within N-doped porous two-dimensional carbon nanosheets: a high-performance hydrogen evolution reaction catalyst
Develo** cost-effective electrocatalysts with high activity and stability especially at high current density is of great significance for the large-scale commercial application of electrochemical water split...
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Article
Functional connectivity disruption of insular subregions in the cirrhotic patients with minimal hepatic encephalopathy
We investigated abnormal functional connectivity (FC) patterns of insular subregions in patients with minimal hepatic encephalopathy (MHE) and examined their relationships with cognitive dysfunction using rest...
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Article
Author Correction: Perioperative toripalimab and chemotherapy in locally advanced gastric or gastro-esophageal junction cancer: a randomized phase 2 trial
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Article
Perioperative toripalimab and chemotherapy in locally advanced gastric or gastro-esophageal junction cancer: a randomized phase 2 trial
Perioperative chemotherapy is the standard treatment for locally advanced gastric or gastro-esophageal junction cancer, and the addition of programmed cell death 1 (PD-1) inhibitor is under investigation. In t...
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Article
Open AccessComprehensive assessment of fine motor movement and cognitive function among older adults in China: a cross-sectional study
Fine motor skills are closely related to cognitive function. However, there is currently no comprehensive assessment of fine motor movement and how it corresponds with cognitive function. To conduct a complete...
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Chapter and Conference Paper
Application of Fracturing and Completion Technology in Sichuan-Chongqing Continental Tight Sandstone Reservoir
Tight sandstone gas reservoir is a very important unconventional oil and gas resource, but its reservoir physical property is poor, permeability is low, and exploitation is difficult. The existing fracturing a...
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Article
Open AccessND630 controls ACACA and lipid reprogramming in prostate cancer by regulating the expression of circKIF18B_003
ND630 is believed to be a new therapy pharmacologic molecule in targeting the expression of ACACA and regulating the lipid metabolism. However, the function of ND630 in prostate cancer remains unknown. KIF18B,...
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Article
Improving Blood Monocyte Energy Metabolism Enhances Its Ability to Phagocytose Amyloid-β and Prevents Alzheimer’s Disease-Type Pathology and Cognitive Deficits
Deficiencies in the clearance of peripheral amyloid β (Aβ) play a crucial role in the progression of Alzheimer’s disease (AD). Previous studies have shown that the ability of blood monocytes to phagocytose Aβ ...
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Article
Mechanical Strong, Highly Adhesive, Recyclable and Transparent Supramolecular Silicone Coatings with Easy Water/Oil Sliding
Traditional silicone materials have poor mechanical properties, poor interfacial adhesion and lack the ability to be reprocessed or recycled. Herein, we developed a novel strategy of incorporating dynamic nonc...
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Article
Open AccessDevelopment and evaluation of short-form version of the Constitution in Chinese Medicine Questionnaire: study a new and best brief instrument of Chinese medicine for health management
More efficient instruments for body constitution identification are needed for clinical practice. We aimed to develop the short-form version of the Constitution in Chinese Medicine Questionnaire (CCMQ) and eva...
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Article
Open AccessEndocytosis-mediated entry of a caterpillar effector into plants is countered by Jasmonate
Insects and pathogens release effectors into plant cells to weaken the host defense or immune response. While the imports of some bacterial and fungal effectors into plants have been previously characterized, ...
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Article
Flat-leaf submerged plants are more sensitive to invasion intensity and water nutrition levels than needle-leaf ones
Plant invasion and water eutrophication severely damage wetland plant growth. However, the effects of plant invasion and water nutrient levels on the growth of submerged plants with different leaf types remain...
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Article
Open AccessCamrelizumab combined with apatinib in patients with first-line platinum-resistant or PD-1 inhibitor resistant recurrent/metastatic nasopharyngeal carcinoma: a single-arm, phase 2 trial
Immunotherapy combined with antiangiogenic targeted therapy has improved the treatment of certain solid tumors, but effective regimens remain elusive for refractory recurrent/metastatic nasopharyngeal carcinom...
