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Article
Open AccessFTO deficiency in older livers exacerbates ferroptosis during ischaemia/reperfusion injury by upregulating ACSL4 and TFRC
Older livers are more prone to hepatic ischaemia/reperfusion injury (HIRI), which severely limits their utilization in liver transplantation. The potential mechanism remains unclear. Here, we demonstrate older...
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Article
Inhibitory Mechanisms of Plant Volatile 1-Octanol on the Germination of Aspergillus Flavus Spores
Biogenic volatile organic compounds have promising applications in controlling fungal spoilage of postharvest agro-products and perishable foods. In a previous study, we discovered that the plant volatile 1-oc...
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Article
Modular dimerization of organic radicals for stable and dense flow battery catholyte
Aqueous organic redox flow batteries (AORFBs) hold promise for safe, sustainable and cost-effective grid energy storage. However, develo** catholyte redox molecules with the desired stability, power and ener...
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Article
Open AccessWidely targeted quantitative lipidomics and prognostic model reveal plasma lipid predictors for nasopharyngeal carcinoma
Dysregulation of lipid metabolism is closely associated with cancer progression. The study aimed to establish a prognostic model to predict distant metastasis-free survival (DMFS) in patients with nasopharynge...
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Article
Protection of postharvest grains from fungal spoilage by biogenic volatiles
Fungal spoilage of postharvest grains poses serious problems with respect to food safety, human health, and the economic value of grains. The protection of cereal grains from deleterious fungi is a critical ai...
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Article
Open AccessComparing the effectiveness and safety of Sorafenib plus TACE with Apatinib plus TACE for treating patients with unresectable hepatocellular carcinoma: a multicentre propensity score matching study
Local combined systemic therapy has been an important method for the treatment of unresectable hepatocellular carcinoma (HCC).The purpose of this study was to compare the effectiveness and safety of transarter...
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Article
Short-term effect of ambient temperature and ambient temperature changes on the risk of warts outpatient visits in Hefei, China: a retrospective time-series study
Concerns are growing about the adverse health effects of ambient temperature and ambient temperature changes. However, the association between ambient temperature and ambient temperature changes on the risk of...
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Article
In situ phytostabilization of arable soils severely contaminated with cadmium at Yangshuo, Southern China, using cash crops and amendments: a comprehensive performance evaluation
Phytostabilization is known to be a promising technique to prevent the off-site movement of cadmium (Cd) from severely contaminated arable soils. Previous studies have recognized plants and amendments that cou...
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Article
Prospective study of light dark matter search with a newly proposed DarkSHINE experiment
Dark photons have been well motivated as strong candidates for dark force carriers and light dark matter in the sub-GeV mass range. Compared with collider experiments, fixed-target experiments provide a comple...
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Article
Open AccessCollective outbreak of severe acute histoplasmosis in immunocompetent Chinese in South America: the clinical characteristics and continuous monitoring of serum cytokines/chemokines
Acute histoplasmosis is a rare fungal disease in China. This study is aimed to summarize the clinical characteristics of the first large-scale outbreak of imported acute histoplasmosis in Chinese, so as to pro...
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Article
The antifungal mechanisms of plant volatile compound 1-octanol against Aspergillus flavus growth
The exploitation of active ingredients from plant volatile organic compounds as natural gaseous fungicides shows remarkable potential for controlling fungal decay in postharvest agroproducts. Although 1-octano...
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Article
Porous sodium titanate nanofibers for high energy quasi-solid-state sodium-ion hybrid capacitors
Sodium-ion hybrid capacitors (SICs) have considered as promising candidate for lithium-ion counterpart in large-scale energy storage due to their advantages of natural abundance, potential low cost, and high e...
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Article
Open AccessSecretory quality control constrains functional selection-associated protein structure innovation
Biophysical models suggest a dominant role of structural over functional constraints in sha** protein evolution. Selection on structural constraints is linked closely to expression levels of proteins, which ...
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Article
Transcriptomics analyses and biochemical characterization of Aspergillus flavus spores exposed to 1-nonanol
The exploitation of plant volatile organic compounds as biofumigants to control postharvest decaying of agro-products has received considerable research attention. Our previous study reported that 1-nonanol, t...
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Article
Parameter inversion of probability integral method based on improved crow search algorithm
Coal mining can cause surface movement and deformation, which can lead to serious geological disasters. The prediction of mining subsidence is not only the basis of evaluation of mining to damage, but also the...
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Article
Open AccessCircCD44 plays oncogenic roles in triple-negative breast cancer by modulating the miR-502–5p/KRAS and IGF2BP2/Myc axes
Emerging studies have revealed the potent functions of circRNAs in breast cancer tumorigenesis. However, the biogenesis, biofunction and mechanism of circRNAs in triple-negative breast cancer (TNBC) are largel...
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Article
Open AccessYinQiSanHuang Jiedu decoction for the treatment of hepatitis B-related compensated liver cirrhosis: study protocol for a multi-center randomized controlled trial
Hepatitis B-related compensated liver cirrhosis is related to a higher risk of hepatocellular carcinoma, and antiviral therapy is the preferred method. As the pathological mechanisms of liver fibrosis are comp...
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Article
Antifungal mechanism of 1-nonanol against Aspergillus flavus growth revealed by metabolomic analyses
Chemical control of fungal spoilage of postharvest cereal grains is an important strategy for the management of grain storage. Here, the potential antifungal activity of 1-nonanol, a main component of cereal v...
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Article
Double-endpoint Genotoxicity Quantification and PAHs Characterization of Drinking Water Source alongside Polluted Yinghe River with High Tumor Mortality
The etiology for the high tumor mortality in heavy polluted Yinghe river basin is still unclear and polycyclic aromatic hydrocarbons (PAHs) belong to the priority pollutants in water based on the former survei...
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Article
Open AccessEarly triage of critically ill COVID-19 patients using deep learning
The sudden deterioration of patients with novel coronavirus disease 2019 (COVID-19) into critical illness is of major concern. It is imperative to identify these patients early. We show that a deep learning-ba...
